Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death

Cell Calcium
S MarchiP Pinton

Abstract

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures, as they intimately communicate, forming very dynamic platforms termed mitochondria-associated membranes (MAMs). In particular, the ER transmits proper Ca2+ signals to mitochondria, which decode them into specific inputs to regulate essential functions, including metabolism, energy production and apoptosis. Here, we will describe the different molecular players involved in the transfer of Ca2+ ions from the ER lumen to the mitochondrial matrix and how modifications in both ER-mitochondria contact sites and Ca2+ signaling can alter the cell death execution program.

Citations

Jul 11, 2018·Biology of the Cell·Morgan Gallazzini, Nicolas Pallet
Feb 2, 2019·Anesthesiology·Renjini Ramadasan-NairMargaret M Sedensky
Mar 3, 2018·Cell Death & Disease·Patricia Gómez-SuagaMireia Niso-Santano
Mar 8, 2018·Cell Death & Disease·Benjamin DelpratCécile Delettre
Apr 30, 2019·Cell Cycle·Saverio MarchiPaolo Pinton
Oct 4, 2019·Antioxidants & Redox Signaling·Hsin Yao ChiuReshma Taneja
Dec 25, 2019·Antioxidants & Redox Signaling·Yanjie ZhangGuangdong Yang
Jan 15, 2020·The International Journal of Neuroscience·Yingjiao LiNanchang Xie
Mar 21, 2020·Journal of Extracellular Vesicles·Jack TaylorMary Bebawy
Apr 6, 2020·European Journal of Applied Physiology·Allyson M SchweitzerIrena A Rebalka
May 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Geeta RaoPriyabrata Mukherjee
Sep 15, 2020·The Journal of Cell Biology·Samuel A KillackeyStephen E Girardin
Sep 22, 2019·Cells·Dmitry NamgaladzeBernhard Brüne
Nov 17, 2019·International Journal of Molecular Sciences·Changhwan AhnEui-Bae Jeung
May 22, 2020·Molecular and Cellular Biochemistry·Muhammad AfzalKhalil Ahmed
Jul 24, 2020·Scientific Reports·Nsrein AliSeppo J Vainio
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiang HeWei Lu
Jul 14, 2017·Cellular and Molecular Life Sciences : CMLS·Anna Melkov, Uri Abdu
Jan 3, 2019·The Journal of Clinical Investigation·Estela Area-GomezSerge Przedborski
Dec 18, 2018·F1000Research·Giorgia PallafacchinaRosario Rizzuto
Aug 18, 2020·Reproductive Biology and Endocrinology : RB&E·Feng WangXiang-Hong Ou
Sep 4, 2020·Current Protocols in Toxicology·Gabriela Assis-de-LemosAntonio Galina
Mar 29, 2018·Biochemical Society Transactions·Francesca Giordano
Aug 26, 2018·Nature Reviews. Molecular Cell Biology·Carlotta GiorgiPaolo Pinton

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