Mitochondrial and postmitochondrial survival signaling in cancer

Mitochondrion
Neelu Yadav, Dhyan Chandra

Abstract

Cancer cells are resistant to conventional chemotherapy and radiotherapy, however, the molecular mechanisms of resistance to therapy remain unclear. Cellular survival machinery protects mitochondrial integrity against endogenous or exogenous stresses. Prodeath molecules orchestrate around mitochondria to initiate and execute cell death in cancer, and also play an underappreciated role in survival of cancer cells. Prosurvival mechanisms can operate at mitochondrial and postmitochondrial levels to attenuate core apoptotic death program. It is intriguing to explore how prosurvival and prodeath molecules crosstalk to regulate mitochondrial functions leading to increased cancer cell survival. This review describes some putative survival mechanisms at mitochondria, which may play a role in designing effective agents for cancer prevention and therapy. These survival pathways may also have significance in understanding other human pathophysiological conditions including diabetes, cardiovascular, autoimmune, and neurodegenerative diseases.

References

Dec 1, 1991·Journal of Molecular and Cellular Cardiology·R B JenningsC Steenbergen
Jan 1, 1990·Archives of Biochemistry and Biophysics·G Xie, J E Wilson
Apr 1, 1987·European Journal of Biochemistry·D W NicholsonW Neupert
May 26, 1995·The Journal of Biological Chemistry·A MayerR Lill
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·A G UrenD L Vaux
Jan 1, 1996·Annual Review of Biochemistry·R O Poyton, J E McEwen
Jan 1, 1997·Annual Review of Biochemistry·P D Boyer
Aug 8, 1997·The Journal of Biological Chemistry·K B Beckman, B N Ames
Dec 9, 1997·Cell·G S Salvesen, V M Dixit
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Nov 13, 1998·Science·M H CardoneJ C Reed
Aug 15, 2000·The Journal of Biological Chemistry·X Jiang, X Wang
Aug 22, 2000·The Journal of Biological Chemistry·S M SrinivasulaE S Alnemri
Feb 7, 2001·The Journal of Cell Biology·P G EkertD L Vaux
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·H L Vieira, G Kroemer
May 10, 2001·Mutation Research·J S PentaW C Copeland
Aug 30, 2001·Cell Stress & Chaperones·A SamaliS Orrenius
Sep 5, 2001·Nature Cell Biology·L RavagnanG Kroemer
Sep 13, 2001·The Journal of Biological Chemistry·K CainG M Cohen
Dec 26, 2001·The Journal of Biological Chemistry·John G PastorinoJan B Hoek
Mar 20, 2002·Current Molecular Medicine·M Olson, S Kornbluth
May 9, 2002·Biochimica Et Biophysica Acta·Alan E SeniorJoachim Weber
Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
Oct 31, 2002·The Journal of Biological Chemistry·Dhyan ChandraDean G Tang
Nov 15, 2002·Developmental Cell·Sandeep Robert DattaMichael E Greenberg

❮ Previous
Next ❯

Citations

Dec 18, 2015·Biochimica Et Biophysica Acta·Yang Zhang, Michael R Maurizi
Dec 3, 2015·Free Radical Biology & Medicine·Neelu YadavDhyan Chandra
Aug 25, 2015·European Journal of Pharmacology·Alane Pereira CortezMarize Campos Valadares
Jul 13, 2014·Biochimica Et Biophysica Acta·Fang HaoDhyan Chandra
Oct 22, 2016·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Kai Sheng, Jiahuan Lu
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-Mei MaoQiong-Hua Chen
Jun 20, 2017·Journal of Agricultural and Food Chemistry·Wei-Chao SuQing-Xi Chen
Sep 6, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhi-Hua XuBo Li
Nov 30, 2015·Biochemistry. Biokhimii︠a︡·M A Savitskaya, G E Onishchenko
Nov 2, 2019·British Journal of Cancer·Sandeep KumarDhyan Chandra
Feb 6, 2016·Molecular Medicine Reports·Hui ChenYu-Ling Liu
Mar 17, 2017·Scientific Reports·Kévin HardonnièreDominique Lagadic-Gossmann
Aug 24, 2016·Cancer Research·Luay M AlmassalhaVadim Backman
May 27, 2020·Trends in Cancer·Jordan O'MalleyDhyan Chandra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis