Mitochondrial Bioenergetics and Dynamics in Secretion Processes.

Frontiers in Endocrinology
Jennyfer MartínezCelia Quijano

Abstract

Secretion is an energy consuming process that plays a relevant role in cell communication and adaptation to the environment. Among others, endocrine cells producing hormones, immune cells producing cytokines or antibodies, neurons releasing neurotransmitters at synapsis, and more recently acknowledged, senescent cells synthesizing and secreting multiple cytokines, growth factors and proteases, require energy to successfully accomplish the different stages of the secretion process. Calcium ions (Ca2+) act as second messengers regulating secretion in many of these cases. In this setting, mitochondria appear as key players providing ATP by oxidative phosphorylation, buffering Ca2+ concentrations and acting as structural platforms. These tasks also require the concerted actions of the mitochondrial dynamics machinery. These proteins mediate mitochondrial fusion and fission, and are also required for transport and tethering of mitochondria to cellular organelles where the different steps of the secretion process take place. Herein we present a brief overview of mitochondrial energy metabolism, mitochondrial dynamics, and the different steps of the secretion processes, along with evidence of the interaction between these pathways. We...Continue Reading

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Citations

Aug 28, 2020·International Journal of Molecular Sciences·Rosita CurcioVincenza Dolce
Nov 13, 2020·Molecular Neurobiology·Shweta Goyal, Rajnish Kumar Chaturvedi

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Methods Mentioned

BETA
GTPases
nucleotide exchange
glucosylation
ubiquitination
GTPase
protein folding
transgenic

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