PMID: 8593085Feb 1, 1996Paper

Mitochondrial bioenergetics as affected by cationic detergents

Archives of Environmental Contamination and Toxicology
M Bragadin, P Dell'Antone

Abstract

This paper examines the accumulation and toxicity mechanism of a cationic detergent, cetyltrimethylammonium (bromide) (CTAB), in energized rat liver mitochondria. The results suggest that: (1) the CTAB ion is accumulated in the mitochondrial matrix by a membrane potential-driven uptake mechanism; (2) accumulation may lead to a toxic effect, since it gives rise to collapse of the mitochondrial membrane potential (delta phi) which is correlated with ATP synthesis and which regulates Ca++ uptake; (3) collapse of delta phi may be due to enhanced permeability of the mitochondrial membrane to the ions (detergent effect); and (4) delta phi collapse and Ca++ and K+ release were also observed in another cationic detergent, NTAB, but not in the presence of anionic detergents.

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Citations

May 18, 2001·Analytical Biochemistry·M BragadinG Scutari
Apr 13, 2007·Cell Biology and Toxicology·S L LevineV Papadopoulos
Feb 6, 2002·Chemosphere·Marcantonio BragadinSabrina Manente
Jul 7, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eman ElmahjoubiVictor M Meidan
Feb 6, 2007·Chemistry and Physics of Lipids·Joana MarcelinoCarla Matos
Nov 17, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Reginald C AdieleCollins Kamunde
Mar 14, 2008·Colloids and Surfaces. B, Biointerfaces·Jung-Hua Steven KuoJo-Wen Tseng
Mar 15, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Norbert LukacPeter Massanyi
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·N R Pumford, N C Halmes
Jul 15, 2020·Andrologia·Mahdi MalmirHamideh Khodabandelo

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