Mitochondrial bioenergetics, redox state, dynamics and turnover alterations in renal mass reduction models of chronic kidney diseases and their possible implications in the progression of this illness

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Omar Emiliano Aparicio-TrejoJosé Pedraza-Chaverri

Abstract

Nowadays, chronic kidney disease (CKD) is considered a worldwide public health problem. CKD is a term used to describe a set of pathologies that structurally and functionally affect the kidney, it is mostly characterized by the progressive loss of kidney function. Current therapeutic approaches are insufficient to avoid the development of this disease, which highlights the necessity of developing new strategies to reverse or at least delay CKD progression. Kidney is highly dependent on mitochondrial homeostasis and function, consequently, the idea that mitochondrial pathologies could play a pivotal role in the genesis and development of kidney diseases has risen. Although many research groups have recently published studies of mitochondrial function in acute kidney disease models, the existing information about CKD is still limited, especially in renal mass reduction (RMR) models. This paper focuses on reviewing current experimental information about the bioenergetics, dynamics (fission and fusion processes), turnover (mitophagy and biogenesis) and redox mitochondrial alterations in RMR, to discuss and integrate the mitochondrial changes triggered by nephron loss, as well as its relationship with loss of kidney function in CKD,...Continue Reading

Citations

Sep 16, 2020·Journal of Clinical Medicine·Ahmad AgilGumersindo Fernández-Vázquez
Sep 27, 2019·Current Developments in Nutrition·Rattiyaporn Kanlaya, Visith Thongboonkerd
Aug 26, 2018·European Journal of Clinical Investigation·Denise MafraFerdinand von Walden
Sep 28, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sabino Hazael Avila-RojasJosé Pedraza-Chaverri
Nov 17, 2020·Frontiers in Physiology·Sakdithep Chaiyarit, Visith Thongboonkerd
Jun 3, 2021·Free Radical Biology & Medicine·Ana Karina Aranda-RiveraJosé Pedraza-Chaverri
Jun 28, 2021·Free Radical Biology & Medicine·Alexis Paulina Jiménez-UribeJosé Pedraza-Chaverri
Jun 15, 2021·Frontiers in Pharmacology·Qing LiYanggang Yuan
Aug 28, 2021·Biomolecules·Ana Karina Aranda-RiveraJosé Pedraza-Chaverri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
A P ProvoostJ C Molenaar
Frontiers in Cellular Neuroscience
Qian Cai, Prasad Tammineni
Advances in Experimental Medicine and Biology
Pu Duann, Pei-Hui Lin
© 2022 Meta ULC. All rights reserved