Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Shireesh SrivastavaRichard L Veech

Abstract

We measured the effects of a diet in which D-β-hydroxybutyrate-(R)-1,3 butanediol monoester [ketone ester (KE)] replaced equicaloric amounts of carbohydrate on 8-wk-old male C57BL/6J mice. Diets contained equal amounts of fat, protein, and micronutrients. The KE group was fed ad libitum, whereas the control (Ctrl) mice were pair-fed to the KE group. Blood d-β-hydroxybutyrate levels in the KE group were 3-5 times those reported with high-fat ketogenic diets. Voluntary food intake was reduced dose dependently with the KE diet. Feeding the KE diet for up to 1 mo increased the number of mitochondria and doubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regulating proteins in the interscapular brown adipose tissue (IBAT). [(18)F]-Fluorodeoxyglucose uptake in IBAT of the KE group was twice that in IBAT of the Ctrl group. Plasma leptin levels of the KE group were more than 2-fold those of the Ctrl group and were associated with increased sympathetic nervous system activity to IBAT. The KE group exhibited 14% greater resting energy expenditure, but the total energy expenditure measured over a 24-h period or body weights was not different. The quantitative insulin-sensitivity check index w...Continue Reading

References

Nov 1, 1987·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·G EndemannH Brunengraber
Mar 1, 1969·The Journal of Clinical Investigation·O E OwenG F Cahill
Oct 1, 1967·The Journal of Clinical Investigation·O E OwenG F Cahill
May 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K SatoR L Veech
Feb 1, 1994·Metabolism: Clinical and Experimental·J KolanowskiL Landsberg
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Sep 25, 2001·IUBMB Life·R L VeechG F Cahill
Dec 1, 2001·Reviews in Endocrine & Metabolic Disorders·J Himms-Hagen
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haihong ZongGerald I Shulman
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Peter O KwiterovichJohn M Freeman
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Dec 9, 2004·Pediatric Research·Patricia MurphyW McIntyre Burnham
Jun 14, 2005·Biochimica Et Biophysica Acta·Jan NedergaardBarbara Cannon
May 20, 2006·The Journal of Physiology·Richard M Reznick, Gerald I Shulman
Jun 30, 2006·Annals of Neurology·Kristopher J BoughRaymond J Dingledine
Sep 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhidan WuSusan C Stevenson
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hun ChaM Daniel Lane
Feb 15, 2007·American Journal of Physiology. Endocrinology and Metabolism·Adam R KennedyEleftheria Maratos-Flier
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·James A TimmonsBarbara Cannon
Apr 21, 2007·Molecular and Cellular Biochemistry·Hussein M DashtiNaji S Al-Zaid
Aug 9, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mayumi L Prins
Nov 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J WolfgangM Daniel Lane
Apr 2, 2008·Current Atherosclerosis Reports·Frederick F SamahaAngela P Makris
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Natasa PetrovicJan Nedergaard
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Nov 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Matthew D BrussMarc K Hellerstein
Mar 2, 2010·Ageing Research Reviews·Marta BaliettiPatrizia Fattoretti
Apr 9, 2010·Cell Metabolism·Leslie P Kozak
Jul 29, 2010·The Journal of Clinical Investigation·Joseph TamGeorge Kunos
Sep 3, 2010·American Journal of Physiology. Endocrinology and Metabolism·François R JornayvazGerald I Shulman
Sep 24, 2010·Drug News & Perspectives·Cecile VernochetStephen R Farmer

❮ Previous
Next ❯

Citations

Jul 10, 2010·Journal of Biomedical Optics·He N XuLin Z Li
Feb 22, 2014·International Journal of Environmental Research and Public Health·Antonio Paoli
Aug 8, 2014·BioMed Research International·Antonio PaoliGerardo Bosco
Feb 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·David G CotterPeter A Crawford
Jul 24, 2015·Molecular Nutrition & Food Research·Jon MerlinDana S Hutchinson
Aug 6, 2013·Annals of the New York Academy of Sciences·Richard L Veech
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Z AkhtarR J Ploeg
Mar 7, 2014·Journal of Lipid Research·Sami A Hashim, Theodore B VanItallie
Feb 13, 2018·Frontiers in Molecular Neuroscience·Charlotte Veyrat-DurebexHélène Blasco
May 17, 2018·Physiological Reviews·Sofiya GanchevaMichael Roden
Feb 17, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Hunter S WaldmanMatthew J McAllister
Oct 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rachel A H DavisEric P Plaisance
Jan 8, 2019·The Journal of Physiology·Dong-Liang LuZhen-Yu Du
Jul 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angelia Maleah HollandMichael D Roberts
Aug 17, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew J MurrayKieran Clarke
May 27, 2017·Current Medicinal Chemistry·João C P Silva, John G Jones
Jan 4, 2020·Journal of Physiology and Biochemistry·Audrey CarrièreLouis Casteilla
May 24, 2019·Frontiers in Nutrition·Sarah E DeemerEric P Plaisance
Apr 3, 2018·Journal of Nutrition and Metabolism·Vincent J MillerJeff S Volek
Feb 15, 2019·Frontiers in Physiology·Shireesh Srivastava, Richard L Veech
Apr 13, 2019·Nutrients·Elena C GrossDirk Fischer
Sep 25, 2019·International Journal of Molecular Sciences·Úrsula Martínez-GarzaJoana Relat
Dec 22, 2016·Frontiers in Molecular Neuroscience·Csilla AriDominic P D'Agostino
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Patrick C BradshawWilliam M Curtis
Jan 8, 2021·Psychopharmacology·Annika Billefeld BornebuschMorgane Thomsen
Jul 26, 2019·Life Sciences·Rennan de Oliveira CaminhottoFabio Bessa Lima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.