Abstract
We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.
References
Feb 27, 2001·Gene·R Garesse, C G Vallejo
Jan 31, 2002·Annual Review of Medicine·Joel Berger, David E Moller
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Rebecca J TunstallDavid Cameron-Smith
Aug 16, 2002·Nature·Jiandie LinBruce M Spiegelman
Oct 29, 2004·Molecular and Cellular Biology·Tomotake KankiDongchon Kang
Jan 22, 2005·Science·Ulrik WisløffSteven L Britton
Feb 12, 2005·Journal of Applied Physiology·Alejandro LuciaPaul W Franks
May 15, 2007·International Journal of Sports Medicine·Z HeA Lucia
Sep 29, 2007·The Journal of Physiology·Alun G Williams, Jonathan P Folland
Jan 11, 2008·British Journal of Sports Medicine·Z HeA Lucia
Feb 25, 2009·The Journal of Physiology·Jonatan R RuizAlejandro Lucia
May 9, 2009·Scandinavian Journal of Medicine & Science in Sports·C SantiagoA Lucia
May 30, 2009·Journal of Applied Physiology·Nir EynonJosé Oliveira
Sep 1, 2009·Advanced Drug Delivery Reviews·Jose ViñaFederico V Pallardo
Dec 24, 2009·Physiological Genomics·Nir EynonYoav Meckel
Jan 2, 2010·Journal of Applied Physiology·Jonatan R RuizAlejandro Lucia
Citations
Jun 15, 2012·The American Journal of Bioethics : AJOB·Katrina KarkazisSilvia Camporesi
Oct 30, 2010·Journal of Applied Physiology·James A Timmons
Jun 1, 2013·Obesity Surgery·Roberto P da SilvaJorge P Ribeiro
Feb 4, 2014·Journal of Science and Medicine in Sport·Marek SawczukNir Eynon
Jul 4, 2012·Journal of Science and Medicine in Sport·Nir EynonRuth Birk
Jun 10, 2011·Mitochondrion·Nir EynonAlon Eliakim
Nov 29, 2013·Scandinavian Journal of Medicine & Science in Sports·S Ben-ZakenA Eliakim
Mar 25, 2015·European Journal of Sport Science·Shane M HeffernanAlun G Williams
Jul 7, 2016·Journal of Science and Medicine in Sport·Eri Miyamoto-MikamiNoriyuki Fuku
Dec 31, 2015·PloS One·Rebecca GrealyLyn R Griffiths
Nov 1, 2016·Physiological Reports·Thomas YvertNoriyuki Fuku
Nov 17, 2017·BMC Genomics·Camilla J WilliamsJeff S Coombes
May 8, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James P RaleighBrendon J Gurd
May 5, 2011·Physiological Genomics·Nir EynonAlejandro Lucia
May 5, 2011·The Journal of Physiology·Nir EynonAlejandro Lucia
Oct 15, 2013·Scandinavian Journal of Medicine & Science in Sports·A Maciejewska-KarlowskaN Eynon
Oct 2, 2019·Annals of Human Genetics·João Paulo Limongi França Guilherme, Antonio Herbert Lancha
Jul 7, 2015·Scandinavian Journal of Medicine & Science in Sports·C G M SantosR Silva
Jul 8, 2020·Scientific Reports·N R HarveyL R Griffiths
Dec 29, 2019·International Journal of Molecular Sciences·Miroslav PetrPetr Stastny
Dec 22, 2020·Physiological Genomics·João Paulo L F GuilhermeAntonio H Lancha Junior
Apr 29, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C G M SantosR Silva