Mitochondrial biogenesis related endurance genotype score and sports performance in athletes

Mitochondrion
Nir EynonAlejandro Lucia

Abstract

We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P<0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically 'optimal' genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.

Associated Clinical Trials

Sep 12, 2017·Nejc Sarabon

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Citations

Jun 15, 2012·The American Journal of Bioethics : AJOB·Katrina KarkazisSilvia Camporesi
Oct 30, 2010·Journal of Applied Physiology·James A Timmons
Jun 1, 2013·Obesity Surgery·Roberto P da SilvaJorge P Ribeiro
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May 8, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James P RaleighBrendon J Gurd
May 5, 2011·The Journal of Physiology·Nir EynonAlejandro Lucia
Oct 15, 2013·Scandinavian Journal of Medicine & Science in Sports·A Maciejewska-KarlowskaN Eynon
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Apr 29, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C G M SantosR Silva

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