Mitochondrial CK (EC 2.7.3.2) in the human heart

Clinica Chimica Acta; International Journal of Clinical Chemistry
R A WeversJ B Soons

Abstract

CKm, a mitochondrial form of CK, can be isolated from human cardiac muscle. It occurs in two forms, separable on the basis of the difference in net charge. Both molecules have a dimeric structure and consist of two identical subunits. Upon incubation in a human serum, the CK isozyme with the faster cathodal mobility is rapidly converted into the slower form, which has an isoelectric point of 6.94. This makes it impossible to separate this slow CKM form from CK MM (isoelectric point: 6.86) by means of any method that separates on a basis of differences in net charge. Furthermore the two molecules have an almost identical molecular weight. The only difference between the two molecules we have been able to detect is the different behaviour against anti-M antibodies.

References

Feb 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·S WitteveenA van der Laarse
Mar 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A WeversJ B Soons
Jul 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A WeversJ B Soons
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Citations

Jan 1, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·T C Kwong, D A Arvan
Jul 15, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·F KanemitsuJ Mizushima
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Mar 12, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A WeversJ B Soons
Mar 12, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·F KanemitsuJ Mizushima
Nov 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·R J Weselake, H K Jacobs
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