Mitochondrial damage by a new antitumour agent furanonaphthoquinone derivative in human cervical cancer HeLa cells

Journal of Electron Microscopy
J PanS Kuwabara

Abstract

The intracellular ultrastructural changes induced by the new antitumour agent 2-methylnaphtho[2,3-b]furan-4,9-dione (FNQ3) were investigated in human cervical cancer HeLa cells in comparison with normal cervix cells. The normal cells were isolated from cervixes surgically resected from myoma patients and were keratin positive. FNQ3 at 3-5 micrograms ml-1 selectively damaged the HeLa cell mitochondria followed by rough-surfaced endoplasmic reticulum resulting in cell death. In contrast, normal cells remained unaffected at that concentration but were damaged by 20 micrograms ml-1 FNQ3. The FNQ3-induced tumour cell toxicity was inhibited 52% and 36% by trolox and a water-soluble fraction of the antioxidative substance AOB, respectively. The results indicated that FNQ3 is selectively toxic to HeLa cells at approximately eight times that of normal cells in terms of mitochondrial alteration and free radical formation.

Citations

Feb 26, 2003·Cancer Detection and Prevention·Eriko SimamuraJunko Koyama
Jan 23, 2009·Anatomical Science International·Eriko SimamuraKei-Ichi Hirai
Sep 20, 2005·Clinical & Experimental Metastasis·Ana Maria Mendes PereiraManuel Rieber
Mar 28, 1998·Antimicrobial Agents and Chemotherapy·K NagataT Tamura

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