Abstract
Mitochondria can be used as important biomarkers of pollutants on human health, and fine particulate matter (PM2.5) has been documented to cause respiratory damage. However, current studies about the relationship between PM2.5 and mitochondria in respiratory tract are limited and warrant further detailed investigations. Hence, the study was aimed to evaluate effects of PM2.5 on mitochondrial structure, investigate the link between PM2.5-induced mitochondrial disorder and respiratory damage, and delineate the possible mechanisms using both in vitro and in vivo models. PM2.5 exposure resulted in damage of mitochondrial structure, including mitochondrial dynamic, DNA biogenesis and morphological alteration 16HBE cells. Furthermore, PM2.5 elevated ROS formation. However, DPI and NAC (inhibitor of ROS) in supplement restored PM2.5-induced mitochondrial disorder. PM2.5 also contributed to the 16HBE cells apoptosis via mitochondrial pathway. Additionally, the results coincided with the in vivo data which were obtained from bronchial tissues of SD rats exposed to PM2.5 for 30 days. Collectively, this study uncovers that PM2.5 leads to the disorder of mitochondrial structure via ROS generation, and then results in respiratory damage. It...Continue Reading
References
Aug 1, 1995·The Journal of Experimental Medicine·N ZamzamiG Kroemer
Apr 5, 2003·Environmental Health Perspectives·Ning LiAndre Nel
Mar 25, 2004·Nature Reviews. Immunology·J David Lambeth
Aug 9, 2005·Mutation Research·Lotte RisomSteffen Loft
May 18, 2006·Annual Review of Cell and Developmental Biology·David C Chan
Oct 24, 2006·Trends in Pharmacological Sciences·Vera Adam-Vizi, Christos Chinopoulos
Nov 23, 2006·Trends in Cell Biology·Damien Arnoult
Apr 20, 2007·Respiratory Medicine·Isabella Annesi-MaesanoDenis Charpin
Jul 25, 2007·Environmental Pollution·Marilena Kampa, Elias Castanas
Aug 10, 2007·Environmental Health Perspectives·Elvira Vaclavik BräunerSteffen Loft
Sep 7, 2007·Trends in Cell Biology·Ruth Scherz-Shouval, Zvulun Elazar
Jun 12, 2009·Environmental Health : a Global Access Science Source·David M StiebJudith A Leech
Aug 7, 2010·PloS One·Britta MusterKarin Busch
Aug 24, 2010·Mitochondrion·Clare Sheridan, Seamus J Martin
Oct 5, 2010·Toxicology Letters·Ru BaiChunying Chen
Apr 5, 2011·Cell Metabolism·Michael P MurphyChristine C Winterbourn
Aug 26, 2011·Inhalation Toxicology·Regina RückerlAnnette Peters
Mar 20, 2012·Cell·Jodi Nunnari, Anu Suomalainen
Jul 23, 2013·PLoS Biology·Kazuhiko HigashidaDong-Ho Han
May 14, 2014·Toxicology·Xiaoting JinZhuoyu Li
Nov 20, 2014·Particle and Fibre Toxicology·Paul M PeetersCatrin Albrecht
Dec 3, 2014·PloS One·Xiaoting JinHua Ren
Mar 11, 2015·Journal of Cellular Biochemistry·Aishwarya Prakash, Sylvie Doublié
Sep 1, 2015·Pharmacological Reports : PR·Adam SzewczykKrzysztof Zablocki
Citations
Oct 20, 2018·Chinese Medical Journal·Yun-Xia ZhaoXi-Xin Yan
Jun 6, 2020·Critical Reviews in Toxicology·Stéphanie AlkoussaPerrine J Martin
Jun 23, 2020·Nanoscale·Xia ChenHaiwei Xu
Jul 10, 2020·Journal of Cellular and Molecular Medicine·Lu-Hong CongJun Duan
Dec 14, 2018·Toxicology Research·P K Zhou, R X Huang
Jul 6, 2019·Journal of Applied Toxicology : JAT·Xiaoyan MiaoZhixiang Zhou
Jul 4, 2018·International Journal of Environmental Research and Public Health·Ching-Chang ChoChih-Sheng Lin
Dec 7, 2018·Frontiers in Endocrinology·Robert B Hamanaka, Gökhan M Mutlu
Dec 19, 2019·Frontiers in Physiology·Zihan XuXiaobei Deng
May 28, 2020·Scientific Reports·Yabo OuyangXingfu Pan
Jan 5, 2021·Environmental Science and Pollution Research International·Xi LuXixin Yan
Dec 16, 2020·Environmental Pollution·Jahnavi SharmaPradyumna Kumar Mishra
Jan 9, 2021·BMC Public Health·Jianzhong ZhangYuxin Zheng
Oct 3, 2018·Environmental Pollution·B LeclercqG Garçon
Jun 26, 2020·Environment International·J SottyG Garçon
May 2, 2021·Environmental Science and Pollution Research International·Su Hoon LeeSeong Heon Kim
May 10, 2021·Toxicon : Official Journal of the International Society on Toxinology·Man ZhaoJinfeng Cui
May 25, 2021·Frontiers in Physiology·Yixuan ZhangHua Cai
Jul 22, 2021·IUBMB Life·Erika PambianchiGiuseppe Valacchi
Jul 25, 2021·Ecotoxicology and Environmental Safety·Yang LiZhiwei Sun
Apr 18, 2020·Chemical Research in Toxicology·Michal PardoYinon Rudich
Oct 8, 2021·Environmental Science and Pollution Research International·Tianyang ZhaoLin Ye
Oct 26, 2021·The Science of the Total Environment·Chun YangZongwei Cai