Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure

The Journal of Toxicological Sciences
Xiao-Ting JinZhuo-Yu Li

Abstract

Mitochondria can be used as important biomarkers of pollutants on human health, and fine particulate matter (PM2.5) has been documented to cause respiratory damage. However, current studies about the relationship between PM2.5 and mitochondria in respiratory tract are limited and warrant further detailed investigations. Hence, the study was aimed to evaluate effects of PM2.5 on mitochondrial structure, investigate the link between PM2.5-induced mitochondrial disorder and respiratory damage, and delineate the possible mechanisms using both in vitro and in vivo models. PM2.5 exposure resulted in damage of mitochondrial structure, including mitochondrial dynamic, DNA biogenesis and morphological alteration 16HBE cells. Furthermore, PM2.5 elevated ROS formation. However, DPI and NAC (inhibitor of ROS) in supplement restored PM2.5-induced mitochondrial disorder. PM2.5 also contributed to the 16HBE cells apoptosis via mitochondrial pathway. Additionally, the results coincided with the in vivo data which were obtained from bronchial tissues of SD rats exposed to PM2.5 for 30 days. Collectively, this study uncovers that PM2.5 leads to the disorder of mitochondrial structure via ROS generation, and then results in respiratory damage. It...Continue Reading

References

Apr 5, 2003·Environmental Health Perspectives·Ning LiAndre Nel
Mar 25, 2004·Nature Reviews. Immunology·J David Lambeth
Aug 9, 2005·Mutation Research·Lotte RisomSteffen Loft
May 18, 2006·Annual Review of Cell and Developmental Biology·David C Chan
Oct 24, 2006·Trends in Pharmacological Sciences·Vera Adam-Vizi, Christos Chinopoulos
Nov 23, 2006·Trends in Cell Biology·Damien Arnoult
Apr 20, 2007·Respiratory Medicine·Isabella Annesi-MaesanoDenis Charpin
Jul 25, 2007·Environmental Pollution·Marilena Kampa, Elias Castanas
Aug 10, 2007·Environmental Health Perspectives·Elvira Vaclavik BräunerSteffen Loft
Sep 7, 2007·Trends in Cell Biology·Ruth Scherz-Shouval, Zvulun Elazar
Jun 12, 2009·Environmental Health : a Global Access Science Source·David M StiebJudith A Leech
Aug 24, 2010·Mitochondrion·Clare Sheridan, Seamus J Martin
Apr 5, 2011·Cell Metabolism·Michael P MurphyChristine C Winterbourn
Aug 26, 2011·Inhalation Toxicology·Regina RückerlAnnette Peters
Mar 20, 2012·Cell·Jodi Nunnari, Anu Suomalainen
Nov 20, 2014·Particle and Fibre Toxicology·Paul M PeetersCatrin Albrecht
Mar 11, 2015·Journal of Cellular Biochemistry·Aishwarya Prakash, Sylvie Doublié
Sep 1, 2015·Pharmacological Reports : PR·Adam SzewczykKrzysztof Zablocki

❮ Previous
Next ❯

Citations

Jun 6, 2020·Critical Reviews in Toxicology·Stéphanie AlkoussaPerrine J Martin
Jul 6, 2019·Journal of Applied Toxicology : JAT·Xiaoyan MiaoZhixiang Zhou
Jul 4, 2018·International Journal of Environmental Research and Public Health·Ching-Chang ChoChih-Sheng Lin
Dec 7, 2018·Frontiers in Endocrinology·Robert B Hamanaka, Gökhan M Mutlu
Jan 5, 2021·Environmental Science and Pollution Research International·Xi LuXixin Yan
Dec 16, 2020·Environmental Pollution·Jahnavi SharmaPradyumna Kumar Mishra
May 2, 2021·Environmental Science and Pollution Research International·Su Hoon LeeSeong Heon Kim
May 10, 2021·Toxicon : Official Journal of the International Society on Toxinology·Man ZhaoJinfeng Cui
Jul 22, 2021·IUBMB Life·Erika PambianchiGiuseppe Valacchi
Jul 25, 2021·Ecotoxicology and Environmental Safety·Yang LiZhiwei Sun
Oct 8, 2021·Environmental Science and Pollution Research International·Tianyang ZhaoLin Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis