Mitochondrial disorders in multiple sclerosis

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
I A KazantsevaA V Borodin

Abstract

To determine the mitochondrial dysfunction in multiple sclerosis (MS). Fourteen adult patients with MS and 23 healthy people were examined. Cytochemical analysis of lymphocytes in peripheral blood was carried out. The activity of the mitochondrial enzymes involved in metabolism of carbohydrates (lactate dehydrogenase, LDH), amino acids (glutamate dehydrogenase, GDH), fatty acids (alpha-glycerophosphate, α-GPDH) and II complex of the mitochondrial respiratory chain (succinate dehydrogenase, LDH), and the level of lactate in the blood were measured. The activity of α-GPDH was reduced in 62.5% patients and increased in 37.5%. GDH activity in all patients was lowered. LDH activity was reduced in 71.4% patients and compensatory increased in 28.6%. In 66.7% patients, LDH activity was reduced and in 33.3% compensatory increased. Increased blood lactate was observed in 33.3% patients before meal and 44.4% after carbohydrate loading. After carbohydrate loading, in 33.3% patients lactate levels in the blood increased and in 11.1% increased above normal values. Therefore, the enzyme activity have decreased in most patients that suggests the decompensation of mitochondrial function. The results indicate the advisability of administering th...Continue Reading

References

Aug 5, 2008·American Journal of Human Genetics·Hannah R ElliottPatrick F Chinnery
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Ann C McKeeRobert A Stern
Jul 11, 2009·The Journal of Pathology·Maarten E WitteJack van Horssen
Jul 18, 2009·Biochimica Et Biophysica Acta·Peizhong Mao, P Hemachandra Reddy
Jul 22, 2009·Medical Hypotheses·Peter H DuesbergHenry H Bauer
Jun 10, 2010·Acta Neuropathologica·Werner Paulus, Paul Kleihues
Jun 13, 2012·Acta Neuropathologica·Graham R CampbellDon J Mahad
Aug 1, 2013·Indian Journal of Human Genetics·Naeimeh SafavizadehMohamad Zaefizadeh
Sep 28, 2015·Journal of Neurology·Alexander LehnJon Stone
Oct 6, 2015·International Journal of Molecular Sciences·Elvezia Maria ParaboschiRosanna Asselta
Dec 22, 2015·Depression Research and Treatment·Sherri Melrose
Aug 16, 2016·Brain : a Journal of Neurology·Sachin Suresh TiwariKarl Peter Giese
Oct 7, 2016·Investigative Ophthalmology & Visual Science·Nancy A McNamaraRobert L McKown
Jan 26, 2017·Oxidative Medicine and Cellular Longevity·Lelin HuJunjie Wang

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Citations

Aug 28, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A N BoykoO G Kulakova

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