Mitochondrial DNA and ageing

Biochimica Et Biophysica Acta
Aleksandra Trifunovic

Abstract

The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing. Recently, considerable progress in understanding basic mitochondrial genetics and in identifying acquired mtDNA mutations in ageing has been made. Furthermore, the creation of mtDNA-mutator mice has provided the first direct evidence that accelerating the mtDNA mutation rate can result in premature ageing, consistent with the view that loss of mitochondrial function is a major causal factor in ageing. This review will, therefore, focus on recent developments in ageing research related to the role played by mtDNA.

References

Dec 11, 1990·Nucleic Acids Research·G A Cortopassi, N Arnheim
Jan 1, 1988·Annual Review of Cell Biology·G Attardi, G Schatz
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Apr 1, 1982·Cell·D A Clayton
Oct 20, 1995·The Journal of Biological Chemistry·S M Tanhauser, P J Laipis
Oct 1, 1995·Mutation Research·B KadenbachJ Napiwotzki
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·J Müller-HöckerB Kadenbach
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KanedaH Yonekawa
Mar 25, 1994·Nucleic Acids Research·S MelovT E Johnson
Jul 3, 1997·Mutation Research·E WangG Cortopassi
Mar 17, 1999·Biochimica Et Biophysica Acta·G A Cortopassi, A Wong
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J WanagatJ M Aiken
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·J WangN G Larsson
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y WangG Attardi
Apr 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ekaterina NekhaevaKonstantin Khrapko
Aug 23, 2002·The New England Journal of Medicine·Marianne Schwartz, John Vissing
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
May 6, 2003·Biochemical and Biophysical Research Communications·Anne Chomyn, Giuseppe Attardi
Jul 1, 1956·Journal of Gerontology·D HARMAN
May 28, 2004·Nature·Aleksandra TrifunovicNils-Göran Larsson
Aug 18, 2004·Trends in Genetics : TIG·David C SamuelsPatrick F Chinnery
Mar 29, 2005·Neuromuscular Disorders : NMD·Salvatore DiMauro, Michio Hirano
May 13, 2005·Human Molecular Genetics·Nicole HanceAleksandra Trifunovic
Dec 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aleksandra TrifunovicNils-Göran Larsson
Dec 24, 2005·The Journal of Investigative Dermatology·Alex EshaghianJames E Sligh

❮ Previous
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Citations

Sep 24, 2008·Journal of Molecular Evolution·Xiang Jia Min, Donal A Hickey
Sep 9, 2011·The Journal of Biological Chemistry·Elizabeth A StollPhilip J Horner
Sep 25, 2007·Antioxidants & Redox Signaling·Michelangelo MancusoGabriele Siciliano
Jun 5, 2008·Antioxidants & Redox Signaling·Dunyaporn TrachoothamPeng Huang
May 11, 2011·Antioxidants & Redox Signaling·Lucia BiasuttoMario Zoratti
Oct 25, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arnaud BernardJean Demarquoy
Feb 24, 2012·Human Molecular Genetics·Lloye M DillonCarlos T Moraes
Oct 5, 2007·Nucleic Acids Research·Jian-Hua ChenSusan E Ozanne
Apr 29, 2009·Hypertension·Francesco AddabboMichael S Goligorsky
Jul 5, 2008·Expert Review of Molecular Diagnostics·Gabriele SicilianoLuigi Murri
Jun 6, 2012·Expert Opinion on Drug Delivery·Sarandeep Singh Malhi, Rayasa S Ramachandra Murthy
Jan 22, 2013·Mitochondrion·María J López-ArmadaMarta N Valcárcel-Ares
Jan 30, 2010·Medical Hypotheses·Lary C Walker, James G Herndon
Mar 17, 2009·Analytical Biochemistry·Hue-Tran Hornig-DoRudolf J Wiesner
Jun 1, 2008·Proteomics. Clinical Applications·Melanie Y WhiteJennifer E Van Eyk
Oct 13, 2011·BioFactors·Maria Luisa Genova, Giorgio Lenaz
Sep 26, 2009·Journal of Cellular Physiology·Sandro M HirabaraPierre Maechler
Apr 29, 2015·Biochimica Et Biophysica Acta·Eirini LionakiNektarios Tavernarakis
Feb 8, 2011·Mitochondrion·Periyasamy GovindarajKumarasamy Thangaraj
Jul 31, 2007·Cell·Chan Bae ParkNils-Göran Larsson
Jun 4, 2016·International Journal of Molecular Sciences·Enni MarkkanenGrigory L Dianov
Dec 29, 2009·Mutation Research·Ulyana N RotskayaOlga I Sinitsyna
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Britta KleistMicaela Poetsch
Mar 6, 2007·Nature Genetics·Marc VermulstLawrence A Loeb
Mar 2, 2019·Geriatrics & Gerontology International·Koichiro KawaguchiMitsuo Maruyama
Oct 20, 2018·Molecular Neurobiology·Athanasios AlexiouGhulam Md Ashraf
Sep 19, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Hester M den RuijterSaskia C A de Jager
Nov 14, 2019·Current Pharmaceutical Design·Francesco GuarasciGiuseppe Passarino
Jul 1, 2007·Current Opinion in HIV and AIDS·Hélène C F Côté
Dec 20, 2017·International Journal of Radiation Biology·Valeriya N AntipovaNadezhda V Zyrina
Sep 13, 2019·International Journal of Molecular Sciences·Naoimh J O'FarrellJacintha O'Sullivan
Apr 11, 2020·Frontiers in Cell and Developmental Biology·Guo ChenOliver Kepp
Oct 30, 2019·Scientific Reports·Mario BarilaniLorenza Lazzari
Nov 23, 2017·Frontiers in Medicine·Silke RoedderMinnie M Sarwal
Jan 11, 2020·Mechanisms of Ageing and Development·Mansi BabbarVilhelm A Bohr

❮ Previous
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