Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment

Scientific Reports
Parvin KumarCatharina Lavebratt

Abstract

Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number in schizophrenia and bipolar disorder type I, compared to healthy controls. However, it is unknown if mtDNA copy number alteration is driven by psychosis, comorbidity or treatment. Whole blood mtDNA copy number was determined in 594 psychosis patients and corrected for platelet to leukocyte count ratio (mtDNAcnres). The dependence of mtDNAcnres on clinical profile, metabolic comorbidity and antipsychotic drug exposure was assessed. mtDNAcnres was reduced with age (β = -0.210, p < 0.001), use of clozapine (β = -0.110,p = 0.012) and risperidone (β = -0.109,p = 0.014), dependent on prescribed dosage (p = 0.006 and p = 0.026, respectively), and the proportion of life on treatment (p = 0.006). Clozapine (p = 0.0005) and risperidone (p = 0.0126) had a reducing effect on the mtDNA copy number also in stem cell-derived human neurons in vitro at therapeutic plasma levels. For patients not on these drugs, psychosis severity had an effect (β = -0.129, p = 0.017), similar to age (β = -0.159, p = 0.003) and LDL (β = -0.119, p = 0.029) on whole blood mtDNAcnres. Further re...Continue Reading

References

Sep 1, 1988·Gene Analysis Techniques·B Lindblom, G Holmlund
Apr 9, 1981·Nature·S AndersonI G Young
May 1, 1993·Annals of Neurology·C BurkhardtW D Parker
Oct 3, 1999·Schizophrenia Research·R M Post
Feb 27, 2001·Journal of Affective Disorders·T KatoN Kato
Sep 29, 2001·Brain Research Bulletin·N UranovaV Rachmanova
Dec 24, 2002·Journal of Applied Physiology·Stephen WelleCharles A Thornton
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Wade Berrettini
Dec 10, 2003·Archives of Pharmacal Research·Josephine S Modica-NapolitanoJune R Aprille
Nov 10, 2004·Genomics·Kae MunakataTadafumi Kato
Nov 27, 2004·European Archives of Psychiatry and Clinical Neuroscience·Michael RiedelH J Möller
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Hsin-Chen Lee, Yau-Huei Wei
Mar 4, 2005·Journal of Medical Genetics·N CraddockM J Owen
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brett G MasayesvaJoseph Califano
Apr 28, 2006·Brain Research·Teresa Cunha-OliveiraCatarina R de Oliveira
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
May 17, 2006·Journal of Clinical Psychopharmacology·Jonathan RabinowitzMarielle Eerdekens
Nov 18, 2006·Psychiatry and Clinical Neurosciences·Sandeep GroverSubho Chakrabarti
Nov 23, 2006·Antioxidants & Redox Signaling·Stefan W RyterAugustine M K Choi
Mar 17, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Natalya UranovaDiana Orlovskaya
Jun 26, 2007·Journal of Affective Disorders·Michelangelo MancusoGabriele Siciliano
Feb 1, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jorge A QuirozHusseini K Manji
Apr 23, 2008·Annals of Medicine·Ling ShaoMarquis P Vawter
May 27, 2008·Schizophrenia Bulletin·Ping-I Lin, Braxton D Mitchell
May 27, 2008·Schizophrenia Bulletin·Gunvant K Thaker
Feb 26, 2009·Psychiatry Research·Dost OngürPerry F Renshaw
May 12, 2009·Free Radical Biology & Medicine·Alicia J KowaltowskiAnibal E Vercesi
Jul 1, 2009·Mitochondrion·Hitomi UenoMasashi Tanaka
Jul 18, 2009·Muscle & Nerve·Livia PasqualiFrancesco Fornai

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Citations

May 31, 2019·Current Opinion in Psychiatry·Francesco S BersaniOwen M Wolkowitz
Nov 23, 2019·Schizophrenia Bulletin·Federico E TurkheimerAnthony C Vernon
Nov 21, 2019·Bipolar Disorders·Gabriel R FriesJoao Quevedo
Nov 6, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jan KuceraJulie Bienertova-Vasku
Jun 23, 2021·Mitochondrion·Martin Picard
Nov 17, 2020·Journal of Psychiatric Research·Jae Kyung ChungEun-Jeong Joo

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Statistical Package for the Social Sciences

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