Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis

Psychiatry Research
Naruhisa YamakiAkitoyo Hishimoto

Abstract

Numerous evidence indicated mitochondrial abnormalities in the pathophysiology of bipolar disorder (BD); however, it remains unclear whether aberrant mitochondrial DNA (mtDNA) copy number (cn) occur in BD due to the conflicting results in previous studies. Here, peripheral blood mtDNAcn in 69 BD patients and 54 controls were analysed via qPCR. BD patients had significantly lower mtDNAcn compared to controls (regardless of their BD type [BD I or II]). Meta-analysis for all previous BD-mtDNAcn studies combining our results with previously published studies failed to identify any significant association. Meanwhile, Asian-specific meta-analysis remarkably revealed lower mtDNAcn in BD patients.

Citations

May 31, 2019·Current Opinion in Psychiatry·Francesco S BersaniOwen M Wolkowitz
Nov 21, 2019·Bipolar Disorders·Gabriel R FriesJoao Quevedo
Feb 25, 2020·Annual Review of Clinical Psychology·Teresa E DanielsAudrey R Tyrka
Apr 9, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Giselli ScainiJoao Quevedo
Jun 3, 2021·Biomedicines·Ana P MarquesCláudia F Pereira
Jan 4, 2022·The International Journal of Neuropsychopharmacology·Cheng-Chen ChangHui Hua Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Progress in Neuro-psychopharmacology & Biological Psychiatry
Rafael T de SousaRodrigo Machado-Vieira
Journal of Affective Disorders
Ana C AndreazzaLakshmi N Yatham
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
Brent M McGrathPeter H Silverstone
© 2022 Meta ULC. All rights reserved