Mitochondrial DNA diversity in the Polish Roma

Annals of Human Genetics
Boris A MalyarchukD Miścicka-Sliwka

Abstract

Mitochondrial DNA variability in the Polish Roma population has been studied by means of hypervariable segment I and II (HVS I and II) sequencing and restriction fragment-length polymorphism analysis of the mtDNA coding region. The mtDNA haplotypes detected in the Polish Roma fall into the common Eurasian mitochondrial haplogroups (H, U3, K, J1, X, I, W, and M*). The results of complete mtDNA sequencing clearly indicate that the Romani M*-lineage belongs to the Indian-specific haplogroup M5, which is characterized by three transitions in the coding region, at sites 12477, 3921 and 709. Molecular variance analysis inferred from mtDNA data reveals that genetic distances between the Roma groups are considerably larger than those between the surrounding European populations. Also, there are significant differences between the Bulgarian Roma (Balkan and Vlax groups) and West European Roma (Polish, Lithuanian and Spanish groups). Comparative analysis of mtDNA haplotypes in the Roma populations shows that different haplotypes appear to demonstrate impressive founder effects: M5 and H (16261-16304) in all Romani groups; U3, I and J1 in some Romani groups. Interestingly, haplogroup K (with HVS I motif 16224-16234-16311) found in the Pol...Continue Reading

References

Jan 1, 1981·Genetics·M Nei, F Tajima
Apr 9, 1981·Nature·S AndersonI G Young
Nov 6, 1998·Annals of Human Genetics·M B RichardsB C Sykes
Jan 23, 1999·American Journal of Human Genetics·V MacaulayA Torroni
Nov 27, 1999·Current Biology : CB·T KivisildR Villems
Dec 2, 1999·Nature Genetics·L Quintana-MurciA S Santachiara-Benerecetti
Nov 4, 2000·Nature Genetics·P A UnderhillP J Oefner
Mar 17, 2001·Nature Reviews. Genetics·D Schneider
Apr 12, 2001·BMC Medical Genetics·L KalaydjievaF Calafell
May 12, 2001·American Journal of Human Genetics·S FinniläK Majamaa
May 31, 2001·Genome Research·M BamshadL B Jorde
Oct 12, 2001·American Journal of Human Genetics·A TorroniR Scozzari
Nov 13, 2001·American Journal of Human Genetics·D GreshamL Kalaydjieva
Feb 12, 2002·American Journal of Human Genetics·Yong-Gang YaoYa-Ping Zhang
Jan 22, 2003·American Journal of Human Genetics·T KivisildR Villems
Aug 28, 2003·Annals of Human Genetics·B A MalyarchukD Miścicka-Sliwka
Oct 24, 2003·American Journal of Human Genetics·Maere ReidlaRichard Villems
Nov 1, 2003·International Journal of Legal Medicine·T VanecekM Sip
Dec 24, 2003·American Journal of Human Genetics·Lev A ZhivotovskyLuba Kalaydjieva
Dec 25, 2003·European Journal of Human Genetics : EJHG·Vincent DubutNérina Mogentale-Profizi
Jan 15, 2004·European Journal of Human Genetics : EJHG·Doron M BeharKarl Skorecki
Feb 5, 2004·European Journal of Human Genetics : EJHG·R ChaixE Heyer
Feb 7, 2004·Human Biology·Olga BelyaevaSvetlana Limborska
Apr 13, 2004·American Journal of Human Genetics·Lluis Quintana-MurciKen McElreavey
Jul 16, 2004·Molecular Biology and Evolution·Eva-Liis LoogväliRichard Villems
Aug 24, 2004·American Journal of Human Genetics·Bharti MorarLuba Kalaydjieva
Oct 29, 2004·Nature Reviews. Genetics·Mark A Jobling, Peter Gill

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Citations

Nov 18, 2009·American Journal of Physical Anthropology·Alfredo GusmãoLeonor Gusmão
May 8, 2007·International Journal of Cardiology·Hans-Jürgen BandeltAntonio Salas
Sep 30, 2010·American Journal of Physical Anthropology·Maria RegueiroRene J Herrera
May 12, 2012·American Journal of Physical Anthropology·Vânia PereiraMaria João Prata
Sep 15, 2011·American Journal of Physical Anthropology·Marijana Peričić SalihovićBranka Janićijević
Mar 16, 2007·American Journal of Human Genetics·Alessandro AchilliAntonio Torroni
Jan 22, 2008·Annals of Human Genetics·B A MalyarchukP Gomolcak
Oct 18, 2011·Journal of Applied Genetics·Ewa ZiętkiewiczMichał Witt
Jun 27, 2020·Molecular Biology and Evolution·Erica BiancoDavid Comas
Sep 17, 2015·European Journal of Human Genetics : EJHG·Begoña Martínez-CruzDavid Comas

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