Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population

Frontiers in Genetics
Dayan SunXiaofeng Wang

Abstract

Mitochondrial DNA (mtDNA) haplogroups have been associated with functional impairments (i.e., decreased gait speed and grip strength, frailty), which are risk factors of disability. However, the association between mtDNA haplogroups and ADL disability is still unclear. In this study, we conducted an investigation of 25 mtSNPs defining 17 major mtDNA haplogroups for ADL disability in an aging Chinese population. We found that mtDNA haplogroup M7 was associated with an increased risk of disability (OR = 3.18 [95% CI = 1.29-7.83], P = 0.012). The survival rate of the M7 haplogroup group (6.1%) was lower than that of the non-M7 haplogroup group (9.5%) after a 6-year follow-up. In cellular studies, cytoplasmic hybrid (cybrid) cells with the M7 haplogroup showed distinct mitochondrial functions from the M8 haplogroup. Specifically, the respiratory chain complex capacity was significantly lower in M7 haplogroup cybrids than in M8 haplogroup cybrids. Furthermore, an obvious decreased mitochondrial membrane potential and 40% reduced ATP-linked oxygen consumption were found in M7 haplogroup cybrids compared to M8 haplogroup cybrids. Notably, M7 haplogroup cybrids generated more reactive oxygen species (ROS) than M8 haplogroup cybrids. Th...Continue Reading

References

Aug 27, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G De BenedictisC Franceschi
Feb 15, 2000·Advances in Renal Replacement Therapy·J W Rowe, R L Kahn
Sep 21, 1963·JAMA : the Journal of the American Medical Association·S KATZM W JAFFE
Jul 6, 2004·Neuroscience Letters·Joelle M van der WaltMargaret A Pericak-Vance
Oct 8, 2004·European Journal of Human Genetics : EJHG·Serena DatoGiovanna De Benedictis
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin R ShortK Sreekumaran Nair
May 12, 2005·European Journal of Human Genetics : EJHG·Anna-Kaisa Niemi, Kari Majamaa
Feb 3, 2007·American Journal of Human Genetics·Noriyuki FukuMasashi Tanaka
Apr 5, 2007·Nature Protocols·Ilka WittigHermann Schägger
Nov 22, 2007·Aging Cell·Béatrice ChabiDavid A Hood
Dec 19, 2008·Medicine and Science in Sports and Exercise·Robert A ScottYannis P Pitsiladis
Jun 17, 2010·British Journal of Sports Medicine·Eri MikamiMasashi Tanaka
May 29, 2012·Free Radical Biology & Medicine·Shizhen ZhengFuyun Ji
Nov 17, 2012·Nature Reviews. Genetics·Eric A SchonMichio Hirano
Feb 28, 2013·Science Signaling·Sehyun ChaeKyong Soo Park
Apr 2, 2013·The Journal of Clinical Investigation·Douglas C Wallace
Jan 29, 2014·Journal of the American Heart Association·Yanwen QinMin-Xin Guan
Jul 26, 2014·The Journal of Biological Chemistry·Yibo ZhuangAihua Zhang
Sep 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Martin PicardDouglas C Wallace
Nov 14, 2014·Journal of Cross-cultural Gerontology·Danan GuMatthew E Dupre
Jun 13, 2015·International Journal of Epidemiology·Zuyun LiuXiaofeng Wang
Jun 25, 2016·International Journal of Molecular Sciences·Dayan SunJianxin Lyu
Jan 19, 2017·Oncotarget·Mariana Janini GomesMarina Politi Okoshi
Feb 22, 2017·Clinics and Research in Hepatology and Gastroenterology·Cheng ChenXu Guo
Feb 27, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jing SunJennifer A Schrack
Dec 6, 2019·Frontiers in Molecular Biosciences·Dayan SunJiucun Wang
Dec 12, 2019·AIDS Research and Human Retroviruses·Kristine M ErlandsonTodd Hulgan
Jan 15, 2020·Nature Medicine·Sara AhadiMichael Snyder

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Assay

Software Mentioned

LogRank
SPSS

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.