Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Gregory J TranahHealth, Aging and Body Composition Study

Abstract

Mitochondrial DNA (mtDNA) heteroplasmy is a mixture of normal and mutated mtDNA molecules in a cell. High levels of heteroplasmy at specific mtDNA sites lead to inherited mitochondrial diseases with neurological, sensory, and movement impairments. Here we test the hypothesis that heteroplasmy levels in elderly adults are associated with impaired function resembling mild forms of mitochondrial disease. We examined platelet mtDNA heteroplasmy at 20 disease-causing sites for associations with neurosensory and mobility function among 137 participants from the community-based Health, Aging, and Body Composition Study. Elevated mtDNA heteroplasmy at four mtDNA sites in complex I and tRNA genes was nominally associated with reduced cognition, vision, hearing, and mobility: m.10158T>C with Modified Mini-Mental State Examination score (p = .009); m.11778G>A with contrast sensitivity (p = .02); m.7445A>G with high-frequency hearing (p = .047); and m.5703G>A with 400 m walking speed (p = .007). These results indicate that increased mtDNA heteroplasmy at disease-causing sites is associated with neurosensory and mobility function in older persons. We propose the novel use of mtDNA heteroplasmy as a simple, noninvasive predictor of age-relat...Continue Reading

References

Sep 1, 1992·Mutation Research·N Arnheim, G Cortopassi
Jan 1, 1996·Nucleic Acids Research·A M KogelnikD C Wallace
Mar 26, 1999·American Journal of Human Genetics·P F Chinnery, D C Samuels
Jan 29, 2000·Human Mutation·J L LoeffenL P van den Heuvel
Feb 17, 2001·American Journal of Human Genetics·J L ElsonP F Chinnery
Feb 24, 2001·European Journal of Pediatrics·R K Naviaux
May 2, 2001·Nature Reviews. Genetics·J SmeitinkS DiMauro
Feb 21, 2002·Human Molecular Genetics·Alice WongGino A Cortopassi
Jan 9, 2003·Mutation Research·Konstantin KhrapkoWolfram Kunz
Dec 20, 2003·Journal of Medical Genetics·S LebonA Munnich
Mar 23, 2004·Annals of the New York Academy of Sciences·Claudia ZannaMichela Rugolo
Dec 21, 2004·Nucleic Acids Research·Marty C BrandonDouglas C Wallace
Dec 29, 2005·American Journal of Human Genetics·Gavin HudsonPatrick F Chinnery
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth V MenshikovaBret H Goodpaster
Sep 5, 2006·Journal of Medical Genetics·Angela PylePatrick F Chinnery
Jul 10, 2007·RNA Biology·Emily ZifaConstantinos Stathopoulos
Feb 1, 2008·PLoS Biology·James Bruce StewartNils-Göran Larsson
Feb 3, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Holly Van Remmen, Dean P Jones
Feb 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Pedro A FigueiredoJosé A Duarte
Oct 15, 2010·Brain : a Journal of Neurology·Carla GiordanoValerio Carelli
Oct 26, 2010·Journal of Medical Genetics·A S LebreN Boddaert
Nov 30, 2010·Progress in Retinal and Eye Research·Patrick Yu-Wai-ManPatrick F Chinnery
Mar 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Matteo CesariUNKNOWN Health ABC study
Mar 31, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Martin P HoranJ William O Ballard
Jun 5, 2012·Biochimica Et Biophysica Acta·Gregory J TranahUNKNOWN Health, Aging and Body Composition Study
Sep 19, 2012·Immunity & Ageing : I & a·Silvia CatricalaGiovanni Ricevuti
Oct 19, 2012·Human Molecular Genetics·Brendan A I PaynePatrick F Chinnery

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Citations

Jun 30, 2016·Ageing Research Reviews·João Pinto da CostaTeresa Rocha-Santos
Jun 29, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Alan DiotJoanna Poulton
Mar 1, 2018·Biogerontology·Egija Zole, Renāte Ranka
Jul 10, 2018·International Journal of Geriatric Psychiatry·Gregory J TranahUNKNOWN Health, Aging and Body Composition Study
Nov 20, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Willa D BrenowitzKristine Yaffe
Jan 17, 2020·DNA and Cell Biology·Ngoc Ngo Yen NguyenYong Hwa Jo
Jul 10, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tina E BrinkleyStephen B Kritchevsky
Dec 19, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Josef FinstererCarla A Scorza
May 2, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Allen HerbstJonathan Wanagat
Oct 30, 2018·Journal of the American Heart Association·Thomas W BufordGregory J Tranah
Jul 14, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Willa D BrenowitzKristine Yaffe

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