PMID: 8973709Nov 1, 1996Paper

Mitochondrial DNA mutation at nucleotide 1555 in a patient with bilateral sensorineural hearing loss of unknown etiology

Acta Oto-laryngologica
Yuya TamagawaM Nishizawa

Abstract

A mitochondrial DNA mutation at nucleotide 1555 in the ribosomal RNA gene was recently reported as a cause of maternally inherited non-syndromic sensorineural deafness. We assumed that the 1555 mutation is also associated with sporadic non-syndromic deafness and screened for the mutation in seven randomly selected sporadic cases with bilateral sensorineural hearing loss of unknown etiology. The mutation was found in one patient, who first noticed hearing loss when she was in her early teens with subsequent gradual progression. The results suggest that the 1555 mutation may contribute to the etiology of idiopathic bilateral sensorineural hearing loss in some cases.

References

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Jan 1, 1981·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·J Kanzaki, T O-uchi
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Citations

Feb 9, 1999·American Journal of Otolaryngology·M ShohatG J Halpern
Aug 13, 2002·The Laryngoscope·Kotaro IshikawaKeiichi Ichimura
Apr 29, 1999·Acta Oto-laryngologica·T Hutchin
Jun 19, 2009·The Laryngoscope·Yoshiyuki KawashimaKen Kitamura
Feb 3, 2004·The Laryngoscope·Yoshihiro NoguchiKen Kitamura
Aug 1, 1997·The Annals of Otology, Rhinology, and Laryngology·T TsuikiY Tamagawa
Jun 5, 2004·The Laryngoscope·Tatsuo MatsunagaShin-Ichi Usami
Nov 1, 2006·The Laryngoscope·Kotaro IshikawaKeiichi Ichimura

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