Mitochondrial DNA polymorphisms in Italy. III. Population data from Sicily: a possible quantitation of maternal African ancestry.

Annals of Human Genetics
O SeminoA S Santachiara Benerecetti

Abstract

mtDNA polymorphisms were studied in a sample of 90 individuals of the Sicilian population using six restriction enzymes: HpaI, BamHI, HaeII, MspI, AvaII and HincII. (1) Three new patterns, for MspI, AvaII and HincII, have been detected. (2) At least two different mutations were found to account for both the AvaII morph 3 and the AvaII morph 9 as in many other Caucasian groups so far examined. (3) Seventeen types were found; of these six are new. The frequency (54.5%) of type 1-2 (2.1.1.1.1.2) is lower than in the rest of Italy whereas those of type 6-2 (2.1.2.1.1.2) (10.0%) and type 18-2 (2.3.1.4.9*.2) (12.2%) lie at the upper level of the Italian range. The 18-derivative, type 57-2 (2.3.1.4.13*.2), which is consistently found in all Italian samples, is present also among Sicilians with an incidence of 2.2%. (4) Of particular interest is that the HpaI-3/AvaII-3 complex, which is unique to groups of African ancestry, was found in Sicily at a frequency of 4.4%. For the first time an estimate of the amount of gene flow from Blacks to the Sicilian gene pool could be obtained.

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Citations

Dec 1, 1991·Journal of Molecular Evolution·D A MerriwetherD C Wallace
Dec 11, 2008·International Journal of Legal Medicine·V RodríguezA Picornell
Nov 11, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R IvanovaD Charron
Jun 3, 1999·European Journal of Human Genetics : EJHG·P LahermoA Sajantila
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G BarbujaniR Scozzari
Aug 16, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·G VonaL Varesi
Mar 26, 1999·American Journal of Human Genetics·M KringsM Stoneking
Mar 12, 2003·American Journal of Human Genetics·Martin RichardsAntonio Torroni
Feb 12, 2004·American Journal of Human Genetics·Antonio SalasAngel Carracedo
Oct 12, 2001·American Journal of Human Genetics·A TorroniR Scozzari
May 1, 1991·Annals of Human Genetics·O SeminoA S Santachiara Benerecetti

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