Mitochondrial DNA sequence variation in the Anatolian Peninsula (Turkey)

Journal of Genetics
Hatice MergenCihan Oner

Abstract

Throughout human history, the region known today as the Anatolian peninsula (Turkey) has served as a junction connecting the Middle East, Europe and Central Asia, and, thus, has been subject to major population movements. The present study is undertaken to obtain information about the distribution of the existing mitochondrial D-loop sequence variations in the Turkish population of Anatolia. A few studies have previously reported mtDNA sequences in Turks. We attempted to extend these results by analysing a cohort that is not only larger, but also more representative of the Turkish population living in Anatolia. In order to obtain a descriptive picture for the phylogenetic distribution of the mitochondrial genome within Turkey, we analysed mitochondrial D-loop region sequence variations in 75 individuals from different parts of Anatolia by direct sequencing. Analysis of the two hypervariable segments within the noncoding region of the mitochondrial genome revealed the existence of 81 nucleotide mutations at 79 sites. The neighbour-joining tree of Kimura's distance matrix has revealed the presence of six main clusters, of which H and U are the most common. The data obtained are also compared with several European and Turkic Centr...Continue Reading

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Citations

Feb 16, 2012·Annals of Human Genetics·Uğur Hodoğlugil, Robert W Mahley
Nov 16, 2012·PloS One·Mercedes González-RuizAssumpció Malgosa
May 6, 2014·Mitochondrion·Ozgur GuneyHikmet Hakan Aydin
Dec 17, 2008·Forensic Science International. Genetics·Farida AlshamaliWalther Parson
Dec 18, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sefayet KaracaRenato Polimanti
Feb 27, 2015·Journal of Human Genetics·Sefayet KaracaRenato Polimanti
Jun 14, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Marc SimónAssumpció Malgosa
Jul 31, 2014·Molecular Biology Reports·Mustafa SolakAhmet Bestepe
Apr 4, 2006·Journal of Human Genetics·Miguel A Alfonso-SánchezMarian M de Pancorbo
Oct 26, 2019·Mitochondrial DNA. Part B, Resources·Mah Noor MumtazAsifullah Khan
Apr 15, 2020·Genomics·Bassim Muften Ohied, Adnan Issa Al-Badran

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