Mitochondrial DNA transfer to the nucleus generates extensive insertion site variation in maize.

Genetics
Ashley N LoughK J Newton

Abstract

Mitochondrial DNA (mtDNA) insertions into nuclear chromosomes have been documented in a number of eukaryotes. We used fluorescence in situ hybridization (FISH) to examine the variation of mtDNA insertions in maize. Twenty overlapping cosmids, representing the 570-kb maize mitochondrial genome, were individually labeled and hybridized to root tip metaphase chromosomes from the B73 inbred line. A minimum of 15 mtDNA insertion sites on nine chromosomes were detectable using this method. One site near the centromere on chromosome arm 9L was identified by a majority of the cosmids. To examine variation in nuclear mitochondrial DNA sequences (NUMTs), a mixture of labeled cosmids was applied to chromosome spreads of ten diverse inbred lines: A188, A632, B37, B73, BMS, KYS, Mo17, Oh43, W22, and W23. The number of detectable NUMTs varied dramatically among the lines. None of the tested inbred lines other than B73 showed the strong hybridization signal on 9L, suggesting that there is a recent mtDNA insertion at this site in B73. Different sources of B73 and W23 were examined for NUMT variation within inbred lines. Differences were detectable, suggesting either that mtDNA is being incorporated or lost from the maize nuclear genome continu...Continue Reading

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Citations

Dec 12, 2012·Planta·Delene J OldenburgArnold J Bendich
May 17, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Debbie M Figueroa, Hank W Bass
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Jul 9, 2010·New Biotechnology·Wayne Parrott
Jul 18, 2015·Environmental Research·Ryan ClantonGamal Akabani
Apr 3, 2016·Free Radical Biology & Medicine·Katie L LiberatoreShahryar F Kianian
Mar 25, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Stefanie Dukowic-SchulzeChangbin Chen
Apr 6, 2012·Mobile Genetic Elements·Andrew H Lloyd, Jeremy N Timmis
May 26, 2017·Molecular Biology and Evolution·Zhiqiang WuHan Chuan Ong
Sep 1, 2009·American Journal of Botany·Kirsten M WrightAndreas Madlung
May 13, 2020·Genome Génome / Conseil National De Recherches Canada·María J Puertas, Mónica González-Sánchez
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Dec 3, 2016·Biochemistry. Biokhimii︠a︡·Yu M KonstantinovM V Koulintchenko
Jan 25, 2020·International Journal of Molecular Sciences·Guo-Jun ZhangHong-Xing Niu
Apr 17, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Brandeis
Jun 11, 2021·Genome Biology·Guifang LinSanzhen Liu

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