Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA

Biochimica Et Biophysica Acta
Akitsugu SatoJun-Ichi Hayashi

Abstract

In mammalian cells, there is an extensive and continuous exchange of mitochondrial DNA (mtDNA) and its products between mitochondria. This mitochondrial complementation prevents individuals from expression of respiration deficiency caused by mutant mtDNAs. Thus, the presence of mitochondrial complementation does not support the generally accepted mitochondrial theory of aging, which proposes that accumulation of somatic mutations in mtDNA is responsible for age-associated mitochondrial dysfunction. Moreover, the presence of mitochondrial complementation enables gene therapy for mitochondrial diseases using nuclear transplantation of zygotes.

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M AlbringG Attardi
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J HayashiI Nonaka
Dec 29, 1989·Biochemical and Biophysical Research Communications·T C YenY H Wei
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·M M Nass
Apr 1, 1982·Cell·D A Clayton
Jan 1, 1984·Annual Review of Biochemistry·D A Clayton
Apr 9, 1981·Nature·S AndersonI G Young
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·H KanedaH Yonekawa
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Apr 1, 1994·The Journal of Cell Biology·J HayashiI Nonaka
Feb 15, 1994·Microscopy Research and Technique·J Bereiter-Hahn, M Vöth
May 1, 1993·Journal of Neurochemistry·A C BowlingM F Beal
Jan 1, 1995·Annual Review of Genetics·N G Larsson, D A Clayton
Nov 1, 1996·The Journal of Biological Chemistry·B ThyagarajanC Campbell
May 7, 1998·Molecular Human Reproduction·J CohenS Willadsen
Aug 27, 1998·American Journal of Human Genetics·D R MarchingtonJ Poulton
Dec 29, 1998·Trends in Genetics : TIG·P Nagley, Y H Wei
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S ItoJ Hayashi
Mar 5, 1999·Science·D C Wallace
Apr 6, 1999·Proceedings. Biological Sciences·E HagelbergD K Bowden

❮ Previous
Next ❯

Citations

Jun 4, 2010·Antioxidants & Redox Signaling·Yisang YoonTianzheng Yu
May 28, 2010·Molecular Biology of the Cell·Miriam HammermeisterBenedikt Westermann
Aug 14, 2012·Journal of Aging Research·Courtney M PetersonEric Ravussin
Oct 14, 2010·Journal of Cell Science·Arnold Y SeoChristiaan Leeuwenburgh
Aug 19, 2007·Biological Chemistry·Sandra MerzBenedikt Westermann
Nov 9, 2006·Free Radical Research·Rudolf J WiesnerWolfram S Kunz
Oct 28, 2008·Trends in Cell Biology·Annalisa CarlucciAntonio Feliciello
Feb 23, 2008·The International Journal of Biochemistry & Cell Biology·Andrea DlaskováPetr Jezek
Mar 25, 2008·The International Journal of Biochemistry & Cell Biology·Andrea DlaskováPetr Jezek
Jun 4, 2008·Biochimica Et Biophysica Acta·Gilad TwigOrian S Shirihai
May 6, 2009·Biophysical Journal·Pradeep K MouliOrian S Shirihai
Jun 9, 2015·Biochimica Et Biophysica Acta·Brendan A I Payne, Patrick F Chinnery
Mar 14, 2012·Biochimica Et Biophysica Acta·Benedikt Westermann
Jul 13, 2013·The International Journal of Biochemistry & Cell Biology·Emanuele MarzettiChristiaan Leeuwenburgh
Mar 13, 2012·Biochimica Et Biophysica Acta·Ligia C Gomes, Luca Scorrano
Jun 12, 2012·Oxidative Medicine and Cellular Longevity·Enrico DoriaFulvio Marzatico
Aug 21, 2012·Journal of Molecular and Cellular Cardiology·Vanina Romanello, Marco Sandri
May 29, 2016·Biology of the Cell·Giampaolo MorcianoPaolo Pinton
Aug 24, 2017·Journal of Cellular Physiology·Jonathan C VacekNeetu Tyagi
Mar 29, 2008·The Journal of Biological Chemistry·Benedikt Westermann
Sep 26, 2020·Frontiers in Microbiology·Zhihua RenJunliang Deng
Jul 1, 2016·Clinical Science·Miguel A AonSteven J Sollott

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis