Mitochondrial dynamics during spermatogenesis.

Journal of Cell Science
Grigor Varuzhanyan, David C Chan

Abstract

Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially strong in tissues with constitutively high energy demands, such as brain, heart and skeletal muscle. Less is known about the role of mitochondrial dynamics in developmental systems that involve changes in metabolic function. One such system is spermatogenesis. The first mitochondrial dynamics gene, Fuzzy onions (Fzo), was discovered in 1997 to mediate mitochondrial fusion during Drosophila spermatogenesis. In mammals, however, the role of mitochondrial fusion during spermatogenesis remained unknown for nearly two decades after discovery of Fzo Mammalian spermatogenesis is one of the most complex and lengthy differentiation processes in biology, transforming spermatogonial stem cells into highly specialized sperm cells over a 5-week period. This elaborate differentiation process requires several developmentally regulated mitochondrial and metabolic transitions, making it an attractive model system for studying mitochondrial dynamics in vivo We review the emerging role of mitochondrial biology, and especially its dynamics, during the development of the male germ line.

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Citations

Jan 22, 2021·Biochimica Et Biophysica Acta. General Subjects·Grigor VaruzhanyanDavid C Chan
Feb 13, 2021·Cell Calcium·William M RosencransSergey M Bezrukov
Apr 22, 2021·Physiological Reviews·Maria Eugenia Teves, Eduardo R S Roldan
Apr 30, 2021·Journal of Cell Science·Antonina J Kruppa, Folma Buss
Aug 28, 2021·Antioxidants·Zofia E MadejaNatalia Rozwadowska
Sep 9, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuhan WangQiang Weng

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