Mitochondrial Dynamics in Placenta-Derived Mesenchymal Stem Cells Regulate the Invasion Activity of Trophoblast.

International Journal of Molecular Sciences
Jin SeokGi-Jin Kim

Abstract

Mitochondrial dynamics are involved in many cellular events, including the proliferation, differentiation, and invasion/migration of normal as well as cancerous cells. Human placenta-derived mesenchymal stem cells (PD-MSCs) were known to regulate the invasion activity of trophoblasts. However, the effects of PD-MSCs on mitochondrial function in trophoblasts are still insufficiently understood. Therefore, the objectives of this study are to analyze the factors related to mitochondrial function and investigate the correlation between trophoblast invasion and mitophagy via PD-MSC cocultivation. We assess invasion ability and mitochondrial function in invasive trophoblasts according to PD-MSC cocultivation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and extracellular flux (XF) assay. Under PD-MSCs co-cultivation, invasion activity of a trophoblast is increased via activation of the Rho signaling pathway as well as Matrix metalloproteinases (MMPs). Additionally, the expression of mitochondrial function (e.g., reactive oxygen species (ROS), calcium, and adenosine triphosphate (ATP) synthesis) in trophoblasts are increased via PD-MSCs co-cultivation. Finally, PD-MSCs regulate mitochondrial autophagy facto...Continue Reading

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Citations

May 1, 2021·Reproductive Biology·Prasad Pethe, Vaijayanti Kale
Aug 13, 2021·Stem Cell Research & Therapy·Qingyin LinYanzhou Yang
Aug 21, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·María L RojasSusana Genti-Raimondi

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Methods Mentioned

BETA
Enzyme-linked immunosorbent assay
chemical treatment
GTPases
GTPase
PCR
protein assay

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