Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes

Translational Research : the Journal of Laboratory and Clinical Medicine
CiarÁn E FealyJohn P Kirwan

Abstract

The traditional view of mitochondria as isolated, spherical, energy producing organelles, is undergoing a revolutionary change. Emerging data show that mitochondria form a dynamic reticulum that is regulated by cycles of fission and fusion. The discovery of proteins that modulate these activities has led to important advances in understanding human disease. Here, we review the latest evidence that connects the emerging field of mitochondrial dynamics to skeletal muscle insulin resistance and propose some potential mechanisms that may explain the long debated link between mitochondria and the development of type 2 diabetes.

Citations

Nov 25, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jefferson C FrisbeeRobert W Wiseman
Apr 6, 2019·Current Protein & Peptide Science·Johanna AbrigoClaudio Cabello-Verrugio
Oct 28, 2019·International Journal of Molecular Sciences·Matthew T LewisRobert W Wiseman
Jul 30, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Anders E GundersenKai Zou
Jul 15, 2020·Diabetes & Metabolism Journal·Kyung-Soo KimYong-Wook Cho
Oct 19, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Benjamin A KuglerKai Zou
Jan 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun-Won HeoHyo-Bum Kwak
Aug 14, 2020·Mitochondrion·Shrikant Purushottam DharaskarSreedhar Amere Subbarao
May 25, 2021·Archives of Gerontology and Geriatrics·Liang-Kung Chen
Jun 7, 2021·Metabolism: Clinical and Experimental·Christopher L AxelrodJohn P Kirwan

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