Mitochondrial dysfunction: A potential target for Alzheimer's disease intervention and treatment.

Drug Discovery Today
Jia KeQiang Fu

Abstract

Alzheimer's disease (AD) is an irreversible neurodegenerative brain disorder which manifests as a progressive decline in cognitive function. Mitochondrial dysfunction plays a critical role in the early stages of AD, and advances the progression of this age-related neurodegenerative disorder. Therefore, it can be a potential target for interventions to treat AD. Several therapeutic strategies to target mitochondrial dysfunction have gained significant attention in the preclinical stage, but the clinical trials performed to date have shown little progress. Thus, we discuss the mechanisms and strategies of different therapeutic agents for targeting mitochondrial dysfunction in AD. We hope that this review will inspire and guide the development of efficient AD drugs in the future.

References

Apr 27, 2002·Annals of the New York Academy of Sciences·Koji FukuiShiro Urano
Apr 26, 2003·Trends in Biochemical Sciences·Ernesto Carafoli
May 3, 2003·Cell Death and Differentiation·J D RobertsonS Orrenius
Dec 14, 2004·Free Radical Biology & Medicine·Paul S Brookes
Apr 25, 2007·Neurobiology of Aging·Clifford R JackUNKNOWN Members of the Alzheimer's Disease Cooperative Study (ADCS)
May 4, 2007·Archives of Biochemistry and Biophysics·Insil KimJohn J Lemasters
Jan 9, 2008·Current Opinion in Neurology·Terence C ChuaPerminder S Sachdev
Nov 20, 2009·Neurobiology of Aging·Tomohiko SatoToshihiko Iwamoto
Jun 18, 2010·Journal of Alzheimer's Disease : JAD·Shouting ZhangMaria Ankarcrona
Dec 24, 2011·Molecular Neurodegeneration·Yangling Mu, Fred H Gage
May 4, 2012·Molecular Neurobiology·Gunter P EckertWalter E Muller
Jul 16, 2013·Molecular Neurobiology·Chong WangLan Tan
Oct 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hong XieBrian J Bacskai
Jan 9, 2014·Journal of Neural Transmission·Mahesh Ramalingam, Sung-Jin Kim
Feb 11, 2014·Neuron·A Zara Herskovits, Leonard Guarente
May 2, 2014·DNA Repair·William C Copeland, Matthew J Longley
Jun 21, 2014·Biochimica Et Biophysica Acta·D Allan ButterfieldEugenio Barone
Dec 10, 2014·Nature Reviews. Neurology·Florence BurtéPatrick Yu-Wai-Man
Dec 24, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Charles C CaldwellRoberta Diaz Brinton
Jan 17, 2015·Advances in Nutrition·Isha SolankiMordhwaj S Parihar
Jul 30, 2015·Oxidative Medicine and Cellular Longevity·Fabian A Cabezas-OpazoRodrigo A Quintanilla
Aug 1, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Armin von GuntenKarl Überla
Oct 24, 2015·Neurobiology of Disease·A M BertholetP Belenguer
Nov 22, 2015·Pharmacological Reviews·Hagir B Suliman, Claude A Piantadosi
Dec 8, 2015·Journal of Nutritional Science and Vitaminology·Koji FukuiShiro Urano
Dec 24, 2015·Journal of Medicinal Chemistry·Rita M C Di MartinoFederica Belluti
Apr 21, 2016·European Journal of Medicinal Chemistry·Jana HroudováKallol K Ghosh
May 8, 2016·Free Radical Biology & Medicine·Fei YinEnrique Cadenas

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