Mitochondrial dysfunction and cell senescence--skin deep into mammalian aging.

Aging
Joao F Passos, Thomas von Zglinicki

Abstract

Thus, we are again left with a chicken-and egg situation: Is disrupted Ca2+ signalling, reduced mTOR activity and increased autophagy found in SOD2-/- cells because there are more senescent cells in the examined population? Or is any of these factors the culprit that triggers senescence in the first place? While the answer to these questions still eludes us, the study from Campisi and colleagues highlights the importance of mitochondrial dysfunction and cellular senescence in vivo and its impact on the aging process.

References

Jul 25, 2009·Aging Cell·Chunfang WangThomas von Zglinicki
Feb 18, 2010·Molecular Systems Biology·João F PassosThomas von Zglinicki

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Citations

Jun 25, 2015·Carcinogenesis·Amancio CarneroHemad Yasaei
Sep 24, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hiromichi HaraKazuyoshi Kuwano
Mar 5, 2013·Oncotarget·James A McCubreyZoya N Demidenko
Jun 10, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenji KobayashiKazuyoshi Kuwano

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