Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures

Free Radical Biology & Medicine
Manisha Patel

Abstract

Mitochondrial dysfunction has been implicated as a contributing factor in diverse acute and chronic neurological disorders. However, its role in the epilepsies has only recently emerged. Animal studies show that epileptic seizures result in free radical production and oxidative damage to cellular proteins, lipids, and DNA. Mitochondria contribute to the majority of seizure-induced free radical production. Seizure-induced mitochondrial superoxide production, consequent inactivation of susceptible iron-sulfur enzymes, e.g., aconitase, and resultant iron-mediated toxicity may mediate seizure-induced neuronal death. Epileptic seizures are a common feature of mitochondrial dysfunction associated with mitochondrial encephalopathies. Recent work suggests that chronic mitochondrial oxidative stress and resultant dysfunction can render the brain more susceptible to epileptic seizures. This review focuses on the emerging role of oxidative stress and mitochondrial dysfunction both as a consequence and as a cause of epileptic seizures.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J HaileR D Klausner
Jun 1, 1991·Annals of Neurology·F E JensenJ L Burchfiel
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Oct 1, 1995·Free Radical Biology & Medicine·S Goldstein, G Czapski
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·L M CarlssonS L Marklund
Jun 1, 1995·Free Radical Biology & Medicine·A J Bruce, M Baudry
Jul 1, 1995·The International Journal of Biochemistry & Cell Biology·C Richter
Nov 1, 1994·Neuroscience·H PollardY Ben-Ari
Dec 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H Beinert, M C Kennedy
May 1, 1996·Trends in Biochemical Sciences·T A Rouault, R D Klausner
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·K Keyer, J A Imlay
Feb 1, 1997·Bioscience Reports·P R Gardner
Jul 25, 1997·The Journal of Biological Chemistry·I Fridovich
Apr 1, 1997·Journal of Bioenergetics and Biomembranes·N ZamzamiG Kroemer
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Jan 1, 1997·Neurobiology of Disease·R T MatthewsB T Hyman
May 26, 1998·Epilepsy Research·A MoriL Packer
Aug 26, 1998·Biochimica Et Biophysica Acta·M F Beal
Nov 18, 1998·Journal of Neuroscience Research·D X TanG H El-Sokkary
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MelovD C Wallace
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M J FernandesA Nehlig
May 1, 1999·Experimental Neurology·R T MatthewsM F Beal
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y RongM Baudry
Mar 17, 2000·Free Radical Biology & Medicine·L J Roberts, J D Morrow
Apr 13, 2000·The European Journal of Neuroscience·M V FrantsevaP L Carlen
May 9, 2000·The Journal of Biological Chemistry·J Vasquez-VivarM C Kennedy

❮ Previous
Next ❯

Citations

Oct 20, 2009·The Journal of Membrane Biology·Mustafa NaziroğluRamazan Bal
Jun 5, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·N Cárdenas-RodríguezM Ruíz-García
Apr 16, 2013·Cellular and Molecular Neurobiology·Mustafa Nazıroğlu, Vedat Ali Yürekli
Aug 1, 2008·Journal of Biomedical Science·Nimisha SoodAmitava Chakrabarti
Feb 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xiang-ming ZhaMichael J Welsh
Dec 17, 2008·Epilepsia·Hae Sook NohWan Sung Choi
Dec 17, 2008·Epilepsia·Jong M Rho, Raman Sankar
Nov 4, 2008·Biochemistry. Biokhimii︠a︡·L V Matasova, T N Popova
Jun 23, 2011·PloS One·Kellen D WindenJerome Engel
Nov 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Ping LiangManisha Patel
Feb 5, 2008·Genetics·Tim FergestadBarry Ganetzky
Nov 11, 2011·International Journal of Molecular Sciences·Shang-Der ChenYao-Chung Chuang
Mar 1, 2013·Epilepsy Currents·Manisha Patel, Jong M Rho
Apr 12, 2014·Cell and Tissue Research·Ortrud K Steinlein
Aug 1, 2012·Oxidative Medicine and Cellular Longevity·Carlos Clayton Torres AguiarSilvania Maria Mendes Vasconcelos
Jun 27, 2013·Cellular and Molecular Neurobiology·Carlos Clayton Torres AguiarSilvânia Maria Mendes Vasconcelos
Jul 12, 2011·Cellular and Molecular Life Sciences : CMLS·Urszula OleksiewiczGeorge Xinarianos
Dec 2, 2008·Expert Opinion on Pharmacotherapy·P Uma DeviDivya Vohora
Feb 15, 2011·Drug and Chemical Toxicology·Guliz ArmaganAyfer Yalcin
Dec 15, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jaroslava FolbergrováJosef Houštěk
Sep 15, 2015·Journal of Neurochemistry·Catalina Carrasco-PozoKarin Borges
Oct 12, 2010·Pediatric Neurology·Abolfazl MahyarAmir Javadi
Sep 2, 2010·Neuropharmacology·Doodipala Samba ReddySeema Briyal
Aug 17, 2010·Epilepsy Research·R Y L TanS D Shorvon
May 25, 2010·Epilepsy & Behavior : E&B·Susan W Lee, Steve S Chung
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis