Mitochondrial dysfunction and risk of cancer

British Journal of Cancer
M LundJ Vissing

Abstract

Mitochondrial mutations are commonly reported in tumours, but it is unclear whether impaired mitochondrial function per se is a cause or consequence of cancer. To elucidate this, we examined the risk of cancer in a nationwide cohort of patients with mitochondrial dysfunction. We used nationwide results on genetic testing for mitochondrial disease and the Danish Civil Registration System, to construct a cohort of 311 patients with mitochondrial dysfunction. A total of 177 cohort members were identified from genetic testing and 134 genetically untested cohort members were matrilineal relatives to a cohort member with a genetically confirmed maternally inherited mDNA mutation. Information on cancer was obtained by linkage to the Danish Cancer Register. Standardised incidence ratios (SIRs) were used to assess the relative risk of cancer. During 7334 person-years of follow-up, 19 subjects developed a primary cancer. The corresponding SIR for any primary cancer was 1.06 (95% confidence interval 0.68-1.63). Subgroup analyses according to mutational subtype yielded similar results, for example, a SIR of 0.94 (95% CI 0.53 to 1.67) for the m.3243A>G maternally inherited mDNA mutation, cases=13. Patients with mitochondrial dysfunction do ...Continue Reading

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Citations

Apr 29, 2016·Genes, Chromosomes & Cancer·Jenny N PoynterJulie A Ross
May 3, 2019·Journal of Translational Medicine·Lingfei ZhaoJianghua Chen
Jun 9, 2016·Oncotarget·Anna V KudryavtsevaAnastasiya V Snezhkina
Dec 15, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jarosław WalczakJoanna Szczepanowska
Jun 15, 2019·Journal of Bioenergetics and Biomembranes·Dominika MalińskaJoanna Szczepanowska
Apr 25, 2020·Experimental Biology and Medicine·Sheng-Fan WangHsin-Chen Lee
May 24, 2018·Cancer Prevention Research·Fernanda de Souza-TeixeiraVicente Martín
Jun 29, 2021·The Journal of Nutrition, Health & Aging·X Lv, H Niu

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Methods Mentioned

BETA
biopsy
PCR

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