Mitochondrial dysfunction associated with neuronal death following status epilepticus in rat

Epilepsy Research
Hannah R CockMatthew C Walker

Abstract

Status epilepticus (SE) in humans and animal models results in significant cerebral damage and an increased risk of subsequent seizures, associated with a characteristic pattern of neuronal loss particularly affecting the hippocampus. Seizure related cell death is considered to be excitotoxic, but studies have been limited, concentrating on terminal events rather than initial mechanisms. We have studied the biochemical events in the first few days following SE. Self-sustaining limbic SE was induced in adult rats using perforant path stimulation, and animals were allowed to recover. Biochemical studies were performed at 16, 44 h and 8 days following SE, using spectrophotometric enzyme assays and HPLC on regional brain homogenates compared with those from sham-operated controls. Haematoxylin and eosin histology was also undertaken at each time point. Brain aconitase and alpha-ketoglutarate dehydrogenase (alphaKDH) activity were both significantly (P<0.05) reduced by approximately 20% in the first 16-44 h following status, but had returned to normal by 8 days. These enzymes are part of the tri-carboxylic acid (Krebbs) cycle in the mitochondrial matrix, and are known to be sensitive to free radical, especially peroxynitrite damage....Continue Reading

References

Jan 1, 1992·Epilepsia·C M DeGiorgioD M Treiman
Oct 1, 1991·Epilepsy Research·B Meldrum
Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Jun 3, 1989·Lancet·A H SchapiraC D Marsden
Jul 24, 1989·Brain Research·B C RogersH A Tilson
Feb 1, 1989·Journal of Neurochemistry·P RiedererM B Youdim
Mar 30, 1987·Biochemical and Biophysical Research Communications·Y MizunoN Sone
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Dec 1, 1980·Epilepsia·A M Dam
Mar 1, 1995·Journal of Neurobiology·A RepresaY Ben-Ari
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·P R GardnerC W White
Jan 1, 1993·Epilepsia·C G WasterlainR Sankar
Dec 1, 1995·Annals of Neurology·R L Albin
Jan 1, 1996·Methods in Enzymology·J C Drapier, J B Hibbs
Oct 1, 1996·Current Opinion in Neurobiology·M F Beal
Jan 1, 1996·Free Radical Biology & Medicine·J P BolañosJ B Clark
May 1, 1997·Journal of Neurology·M E Gurney
Oct 6, 1997·The Journal of Biological Chemistry·P R GardnerA L Salzman
Jun 6, 1998·The Journal of Biological Chemistry·T GruneK J Davies
Aug 26, 1998·Biochemical and Biophysical Research Communications·U AnderssonE A Newsholme
Aug 28, 1998·Science·D R Green, J C Reed
Jan 23, 1999·Annals of Neurology·S J TabriziA H Schapira
Apr 10, 1999·Nature Neuroscience·A K StoutI J Reynolds

❮ Previous
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Citations

Dec 15, 2010·Journal of Bioenergetics and Biomembranes·Shang-Der ChenYao-Chung Chuang
Jul 24, 2012·Neurocritical Care·Hooman KamelS Andrew Josephson
Feb 26, 2004·Free Radical Biology & Medicine·Li-Ping Liang, Manisha Patel
Mar 11, 2008·Epilepsia·Matthew Walker
May 3, 2014·Annals of Indian Academy of Neurology·Usha Kant MisraSanjeev Kumar Bhoi
Apr 25, 2014·Current Neurology and Neuroscience Reports·Sara HockerW David Freeman
Feb 15, 2011·Drug and Chemical Toxicology·Guliz ArmaganAyfer Yalcin
Jun 5, 2003·Annals of Neurology·Patrick G SullivanTallie Z Baram
Mar 3, 2005·Acta Neurologica Scandinavica·J W PanH P Hetherington
Mar 17, 2007·Acta Neurologica Scandinavica·J W Y ChenC G Wasterlain
Sep 26, 2015·Current Neurology and Neuroscience Reports·Mauricio Ruiz Cuero, Panayiotis N Varelas
Feb 21, 2006·Lancet Neurology·James W Y Chen, Claude G Wasterlain
Jun 5, 2012·Neuropharmacology·Stjepana KovacMatthew C Walker
Nov 24, 2011·Experimental Neurology·Jaroslava FolbergrováRastislav Druga
May 3, 2011·Mitochondrion·Jaroslava Folbergrová, Wolfram S Kunz
Feb 16, 2013·Free Radical Biology & Medicine·Shane Rowley, Manisha Patel
Jun 16, 2011·Neurochemistry International·Eun-Joo ShinHyoung-Chun Kim
Sep 10, 2014·Biochimica Et Biophysica Acta·Sevgi TurkerFeride Severcan
Feb 5, 2015·BioMed Research International·Sreekanth PuttacharyThimmasettappa Thippeswamy
Sep 17, 2004·The International Journal of Neuroscience·Ayfer YalcinEser Y Sozmen
Nov 9, 2017·International Journal of Molecular Sciences·Jennifer N Pearson-Smith, Manisha Patel
Mar 17, 2004·Current Opinion in Neurology·Uwe Heinemann
Oct 2, 2015·Continuum : Lifelong Learning in Neurology·Sara E Hocker
Feb 9, 2019·Journal of Inherited Metabolic Disease·Alfonso Oyarzabal, Isaac Marin-Valencia
Jan 18, 2005·The Journal of Biological Chemistry·In Sup Kil, Jeen-Woo Park

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