Mitochondrial Dysfunction in Age-Related Metabolic Disorders.

Proteomics
Venkateswaran NatarajanKarthik Mallilankaraman

Abstract

Aging is a natural biological process in living organisms characterized by receding bioenergetics. Mitochondria are crucial for cellular bioenergetics and thus an important contributor to age-related energetics deterioration. In addition, mitochondria play a major role in calcium signaling, redox homeostasis, and thermogenesis making this organelle a major cellular component that dictates the fate of a cell. To maintain its quantity and quality, mitochondria undergo multiple processes such as fission, fusion, and mitophagy to eliminate or replace damaged mitochondria. While this bioenergetics machinery is properly protected, the functional decline associated with age and age-related metabolic diseases is mostly a result of failure in such protective mechanisms. In addition, metabolic by-products like reactive oxygen species also aid in this destructive pathway. Mitochondrial dysfunction has always been thought to be associated with diseases. Moreover, studies in recent years have pointed out that aging contributes to the decay of mitochondrial health by promoting imbalances in key mitochondrial-regulated pathways. Hence, it is crucial to understand the nexus of mitochondrial dysfunction in age-related diseases. This review focu...Continue Reading

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Citations

Jul 21, 2020·Experimental Biology and Medicine·Akshaya ChandrasekaranJ Andrés Melendez
Oct 13, 2020·Frontiers in Physiology·Venkateswaran NatarajanKarthik Mallilankaraman
Nov 11, 2020·Experimental Gerontology·Daniel J Moreno Fernández-AyalaGuillermo López-Lluch
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Dan-Dan ZhouHua-Bin Li
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Aug 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Siarhei A DabravolskiAlexander N Orekhov

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