Mitochondrial dysfunction in cancer

Przegla̜d menopauzalny = Menopause review
Kinga Księżakowska-ŁakomaJacek R Wilczyński

Abstract

Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes. In addition, mitochondria are involved in regulation of cell death and reactive oxygen species (ROS) generation. Also, mitochondria play important roles in carcinogenesis via altering energy metabolism, resistance to apoptosis, increase of production of ROS and mtDNA (mitochondrial genome) changes. Studies have suggested that aerobic glycolysis is high in malignant tumors. Probably, it correlates with high glucose intake of cancerous tissues. This observation is contrary to Warburg's theory that the main way of energy generation in cancer cells is non-oxidative glycolysis. Further studies have suggested that in tumor cells both oxidative phosphorylation and glycolysis were active at various rates. An increase of intracellular oxidative stress induces damage of cellular structure and somatic mutations. Further studies confirmed that permanent activity of oxidative stress and the influence of chronic inflammation damage the healthy neighboring epithelium and may lead to carcinogenesis. For instance, c...Continue Reading

Citations

Apr 5, 2020·International Journal of Molecular Sciences·Milena GeorgievaNatalia Krasteva
Sep 29, 2019·Current Drug Targets·Parisa Maleki DanaZatollah Asemi
Jul 28, 2016·Clinical and Translational Medicine·Vicent RibasJosé C Fernández-Checa
Apr 5, 2020·International Journal of Molecular Sciences·Paola Venditti, Sergio Di Meo
May 12, 2018·Biological Trace Element Research·Ahmed A Abd-RabouHanaa H Ahmed
Aug 31, 2019·Oxidative Medicine and Cellular Longevity·Anastasiya V SnezhkinaAlexey A Dmitriev
Nov 13, 2020·Frontiers in Immunology·Katherine KleinJames W Welsh
Dec 12, 2020·International Journal of Molecular Sciences·Shiori MoriHiroki Kuniyasu

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Methods Mentioned

BETA
biopsies

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