Mitochondrial dysfunction in gliomas

Seminars in Pediatric Neurology
Christos D KatsetosPavel Dráber

Abstract

Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation to glycolysis ("Warburg effect"), disturbances in mt membrane potential regulation and apoptotic signaling, as well as to somatic mutations involving the Krebs cycle enzyme isocitrate dehydrogenase. Evolving biological concepts with potential therapeutic implications include interaction between microtubule proteins and mitochondria (mt) in the control of closure of voltage-dependent anion channels and in the regulation of mt dynamics and the mt-endoplasmic reticulum network. The cytoskeletal protein βIII-tubulin, which is overexpressed in malignant gliomas, has emerged as a prosurvival factor associated in part with mt and also as a marker of chemoresistance. Mt-targeted therapeutic strategies that are discussed include the following: (1) metabolic modulation with emphasis on dichloroacetate, a pyruvate dehydrogenase kinase inhibitor; (2) tumor cell death via apoptosis induced by tricyclic antidepressants, microtubule-modulating drugs, and small molecules or compounds capable of inflicting reactive oxygen species-dependent tumor cell death; and (3) pretreatment mt priming...Continue Reading

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Citations

Dec 18, 2013·Seminars in Pediatric Neurology·Christos D KatsetosJoseph J Melvin
Jun 17, 2015·Journal of Neuropathology and Experimental Neurology·Eduarda DráberováChristos D Katsetos
Oct 8, 2015·Preparative Biochemistry & Biotechnology·Lavinia LiguoriDonald K Martin
Oct 7, 2014·Journal of Cellular and Molecular Medicine·Cuiping MaoChangjun Lv
Jul 30, 2014·Cancer Letters·Thomas N SeyfriedPurna Mukherjee
May 16, 2015·Seminars in Pediatric Neurology·Christos D KatsetosPavel Dráber
Sep 8, 2019·Molecular and Cellular Biochemistry·N G KrylovaO I Shadyro
Apr 27, 2019·Neurochemical Research·Thomas N SeyfriedPurna Mukherjee
Aug 10, 2017·The Journal of Biological Chemistry·Natalia FilippovaL Burt Nabors
Dec 1, 2020·IScience·Thomas N SeyfriedChristos Chinopoulos
Jan 30, 2018·Biochimica Et Biophysica Acta. Reviews on Cancer·Catherine J LibbyAnita B Hjelmeland
Jun 3, 2021·International Journal of Molecular Sciences·Mariceli Baia Leão BarrosBárbara do Nascimento Borges
Nov 9, 2021·Molecular Metabolism·Tomás DurajAngel Ayuso-Sacido

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