Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds

Current Neuropharmacology
Lalita GuntukuVeera Ganesh Yerra

Abstract

Gliomas are the most common primary brain tumors either benign or malignant originating from the glial tissue. Glioblastoma multiforme (GBM) is the most prevalent and aggressive form among all gliomas, associated with decimal prognosis due to it`s high invasive nature. GBM is also characterized by high recurrence rate and apoptosis resistance features which make the therapeutic targeting very challenging. Mitochondria are key cellular organelles that are acting as focal points in diverse array of cellular functions such as cellular energy metabolism, regulation of ion homeostasis, redox signaling and cell death. Eventual findings of mitochondrial dysfunction include preference of glycolysis over oxidative phosphorylation, enhanced reactive oxygen species generation and abnormal mitochondria mediated apoptotic machinery are frequently observed in various malignancies including gliomas. In particular, gliomas harbor mitochondrial structure abnormalities, genomic mutations in mtDNA, altered energy metabolism (Warburg effect) along with mutations in isocitrate dehydrogenase (IDH) enzyme. Numerous natural compounds have shown efficacy in the treatment of gliomas by targeting mitochondrial aberrant signaling cascades. Some of the nat...Continue Reading

Citations

Aug 28, 2019·Biomedical Optics Express·Xin FengAnna N Yaroslavsky
Apr 27, 2019·Neurochemical Research·Thomas N SeyfriedPurna Mukherjee
Jan 30, 2020·Antibiotics·Mohammed Saleh Al Aboody, Suresh Mickymaray
Nov 28, 2018·Cells·Zhengqiu ZhouRamon Sun
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Rongze Olivia Lu, Winson S Ho
Jun 3, 2021·International Journal of Molecular Sciences·Mariceli Baia Leão BarrosBárbara do Nascimento Borges
Jul 25, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Evan Rizzel GranDusica Maysinger
Aug 8, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Abdur RaufMohammad Ali Shariati
Sep 7, 2021·Neuromolecular Medicine·Zhihao WuRongze Lu
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Methods Mentioned

BETA
nuclear
xenograft
xenografts

Clinical Trials Mentioned

NCT00540722

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