Mitochondrial dysfunction in high-fat diet-induced nonalcoholic fatty liver disease: The alleviating effect and its mechanism of Polygonatum kingianum

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Xing-Xin YangJie Yu

Abstract

Mitochondrial dysfunction is an important mechanism of non-alcoholic fatty liver disease (NAFLD). Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for NAFLD therapy. In China, Polygonatum kingianum (PK) has been used as a herb and food nutrient for centuries. So far, studies in which the effects of PK on NAFLD are evaluated are lacking. Our study aims at identifying the effects and mechanism of action of PK on NAFLD based on mitochondrial regulation. A NAFLD rat model was induced by a high-fat diet (HFD) and rats were intragastrically given PK (1, 2 and 4 g/kg) for 14 weeks. Changes in body weight, food intake, histological parameters, organ indexes, biochemical parameters and mitochondrial indicators involved in oxidative stress, energy metabolism, fatty acid metabolism, and apoptosis were investigated. PK significantly inhibited the HFD-induced increase of alanine transaminase, aspartate transaminase, total cholesterol (TC), and low density lipoprotein cholesterol in serum, and TC and triglyceride in the liver. In addition, PK reduced high density lipoprotein cholesterol and liver enlargement without affecting food intake. PK also remarkabl...Continue Reading

References

Feb 20, 1999·The Journal of Biological Chemistry·K D ChavinA M Diehl
Apr 30, 1999·Gastroenterology·H Cortez-PintoA M Diehl
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
Jan 12, 2008·World Journal of Gastroenterology : WJG·Yongzhong WeiJamal A Ibdah
Apr 10, 2012·Clinical Biochemistry·Ignazio GrattaglianoPiero Portincasa
Jan 17, 2014·Nature·Jonathan R Friedman, Jodi Nunnari
May 20, 2014·International Journal of Molecular Sciences·Fatiha Nassir, Jamal A Ibdah
Nov 6, 2014·Oxidative Medicine and Cellular Longevity·Aaron M GusdonShen Qu
Jun 2, 2015·Current Drug Targets·Jiao-Ya XuGuang Ji
Aug 9, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne O Oyewole, Mark A Birch-Machin
May 21, 2016·Frontiers in Pharmacology·Nabil EidYoshinori Otsuki
Dec 18, 2016·Trends in Endocrinology and Metabolism : TEM·Nishanth E SunnyKenneth Cusi
Jan 26, 2017·Acta Pharmaceutica Sinica. B·Minting LinJianye Zhang
Mar 5, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hongli YanJie Yu
Jul 6, 2017·Biochemical and Biophysical Research Communications·Frank Edlich
Jul 12, 2017·World Journal of Gastroenterology : WJG·Alessandra FerramoscaVincenzo Zara
Nov 8, 2017·Clinical and Experimental Pharmacology & Physiology·Thekkuttuparambil Ananthanarayanan Ajith
Dec 31, 2017·The International Journal of Biochemistry & Cell Biology·Inês C M SimõesMariusz R Wieckowski
Dec 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Keyang XuJianfeng Bao

❮ Previous
Next ❯

Citations

Aug 1, 2020·Oxidative Medicine and Cellular Longevity·Jian-Kang MuXing-Xin Yang
Nov 5, 2020·Molecular Psychiatry·Wolfgang MarxFelice N Jacka
Aug 28, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hassan Reda Hassan ElsayedRanda El-Gamal
Aug 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian-Kang MuXing-Xin Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis