Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

Molecular Psychiatry
S PrabakaranS Bahn

Abstract

The etiology and pathophysiology of schizophrenia remain unknown. A parallel transcriptomics, proteomics and metabolomics approach was employed on human brain tissue to explore the molecular disease signatures. Almost half the altered proteins identified by proteomics were associated with mitochondrial function and oxidative stress responses. This was mirrored by transcriptional and metabolite perturbations. Cluster analysis of transcriptional alterations showed that genes related to energy metabolism and oxidative stress differentiated almost 90% of schizophrenia patients from controls, while confounding drug effects could be ruled out. We propose that oxidative stress and the ensuing cellular adaptations are linked to the schizophrenia disease process and hope that this new disease concept may advance the approach to treatment, diagnosis and disease prevention of schizophrenia and related syndromes.

References

Jan 1, 1992·Journal of Inherited Metabolic Disease·G K Brown
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·P R GardnerC W White
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K IiharaF Hazama
Aug 22, 1996·Proceedings. Biological Sciences·C RaeG K Radda
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SakanakaR Sasaki
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M van Lookeren CampagneD G Lowe
Jul 29, 2000·Schizophrenia Research·E Fuller TorreyR H Yolken
Oct 29, 2000·Free Radical Biology & Medicine·Y ShiJ E Baker
Jan 5, 2001·Amino Acids·P Saransaari, S S Oja
Mar 21, 2001·Biochimica Et Biophysica Acta·R R RamsayF R van der Leij
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Jan 5, 2002·The Journal of Biological Chemistry·Yasunari SakaiYusaku Nakabeppu
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Apr 13, 2002·Advances in Experimental Medicine and Biology·F R SharpM Bernaudin
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Rakesh NagarajanJeffrey Milbrandt
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kumuda C Das, Carl W White
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Roland H Wenger
Aug 16, 2002·Molecular Biology of the Cell·Marian Groot KoerkampHenk F Tabak
Aug 22, 2002·Redox Report : Communications in Free Radical Research·Junichi Fujii, Yoshitaka Ikeda
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carolina M Maier, Pak H Chan
Nov 8, 2002·International Review of Neurobiology·Leif Hertz, Gerald A Dienel
Nov 8, 2002·International Review of Neurobiology·J P Blass
Nov 8, 2002·International Review of Neurobiology·Alan M JacobsonChristopher M Ryan
Nov 8, 2002·International Review of Neurobiology·David C Henderson, Elissa R Ettinger
Nov 29, 2002·Circulation Research·Ivan T DemchenkoClaude A Piantadosi
Dec 11, 2002·Journal of Neurochemistry·Dorit Ben-Shachar
Feb 4, 2003·The American Journal of Psychiatry·Martina C M RyanJogin H Thakore
Feb 20, 2003·Nature Biotechnology·Steven W TaylorSoumitra S Ghosh
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Sumanta GoswamiAles Cvekl
Apr 29, 2003·Neurochemical Research·Sergei V FedorovichSergei V Konev
May 20, 2003·Biological Chemistry·Ralf Dringen, Johannes Hirrlinger
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marc HeidbrederPeter Dominiak
Jul 25, 2003·The Journal of Experimental Biology·Keith A Webster
Sep 19, 2003·Lancet·Dmitri TkachevSabine Bahn

Citations

May 12, 2005·Acta Neuropathologica·Pawel KreczmanskiChristoph Schmitz
Dec 10, 2009·European Archives of Psychiatry and Clinical Neuroscience·Daniel Martins-de-SouzaSabine Bahn
Nov 23, 2010·European Archives of Psychiatry and Clinical Neuroscience·Daniel Martins-de-SouzaChristoph W Turck
Feb 18, 2011·European Archives of Psychiatry and Clinical Neuroscience·J SteinerGerburg Keilhoff
Feb 24, 2012·Molecules and Cells·Cana Park, Sang Ki Park
Jul 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·E HolmesSarah J Tabrizi
Mar 12, 2009·European Journal of Human Genetics : EJHG·Mathieu EmilyMikkel Heide Schierup
Oct 26, 2011·Molecular Psychiatry·J YangChunling Wan
Jan 4, 2012·Molecular Psychiatry·M MistryPaul Pavlidis
Oct 17, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Anthony AltarStephen D Ginsberg
Jul 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David-Marian OtteAndreas Zimmer
Jul 27, 2012·Translational Psychiatry·S KimM J Webster
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GlattMing T Tsuang
May 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joseph T GlessnerHakon Hakonarson
Oct 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Young-Un ParkSang Ki Park
Dec 17, 2009·Molecular & Cellular Proteomics : MCP·Tammy M K ChengSabine Bahn
Aug 3, 2010·Antioxidants & Redox Signaling·Kodavali V ChowdariVishwajit L Nimgaonkar
Jan 5, 2011·Antioxidants & Redox Signaling·Jeffrey K Yao, Ravinder Reddy
Mar 13, 2008·Schizophrenia Bulletin·Nicholas J Bray
Mar 24, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Julian L Griffin
Feb 15, 2005·BMC Medical Genetics·Daniel R Hanson, Irving I Gottesman
May 2, 2009·BMC Psychiatry·Daniel Martins-de-SouzaEmmanuel Dias-Neto
Aug 7, 2008·Genome Biology·Philipp KhaitovichSabine Bahn
May 26, 2010·Genome Medicine·Benedetta Frida BaldiNicolas Le Novère
Nov 9, 2006·PLoS Medicine·Jeffrey T HuangSabine Bahn
Sep 13, 2007·PloS One·Thomas HansenThomas Werge
Dec 15, 2010·PloS One·Igor V Ovchinnikov, Olga I Kholina
Mar 4, 2014·PloS One·Laramie E DuncanBruce M Cohen
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Yi CheTrevor Young
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Orest Hurko, John L Ryan
Feb 25, 2014·Pharmacology & Therapeutics·Catherine L WinchesterBrian J Morris
Apr 8, 2014·Neuropharmacology·David A MartinCharles D Nichols
Aug 1, 2014·Cellular and Molecular Neurobiology·David-Marian OtteAndreas Zimmer
Nov 22, 2008·Cold Spring Harbor Symposia on Quantitative Biology·M Maletić-SavatićI Pelczer
Feb 13, 2016·Trends in Molecular Medicine·Shira Modai, Noam Shomron
Jan 31, 2016·Molecular and Cellular Neurosciences·Stephen J HaggartyRoy H Perlis
Dec 15, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gordana JevtićNataša D Petronijević
Dec 3, 2014·Schizophrenia Research·Michelle I MighdollThomas M Hyde
Dec 22, 2015·Current Opinion in Neurobiology·Andrew E Jaffe
Nov 30, 2013·Biological Psychiatry·Akiko Hayashi-TakagiKazuya Iwamoto
May 21, 2013·Biological Psychiatry·Andrea SchmittDaniel Martins-de-Souza
Jan 15, 2008·Biological Psychiatry·Ling Shao, Marquis P Vawter
Jan 8, 2008·Journal of Neuroscience Methods·Nader D HalimJoel E Kleinman
Dec 3, 2014·Chemistry & Biology·Julijana IvanisevicGary Siuzdak
May 22, 2007·Journal of Neuroscience Methods·Mary AtzMembers of National Institute of Mental Health Conte Center and Pritzker Neuropsychiatric Disorders Research Consortium
Mar 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dorit Ben-ShacharNanette Freedman
Nov 10, 2015·Trends in Biotechnology·Man K ChanSabine Bahn
Feb 3, 2009·Acta Psychiatrica Scandinavica·J-K SharpeA P Hills
May 29, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Consuelo Walss-BassHenriette Raventos
Apr 19, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chiara MagriSergio Barlati
Apr 3, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ana Mosquera-MiguelAntonio Salas
Nov 26, 2010·Psychiatry and Clinical Neurosciences·Ryo HanzawaHeii Arai
Aug 14, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rebecca E S AnglinPatricia I Rosebush
Feb 18, 2011·Journal of Medical Virology·Hongkai WuXunzhang Wang
Jan 22, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jun ChenQi Xu
Feb 1, 2011·Proteomics. Clinical Applications·Michaela D FiliouDaniel Martins-de-Souza
Jul 21, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gilad SilberbergRuth Navon
Jan 29, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Helena TorrellL Martorell
Jan 26, 2010·Journal of Neurochemistry·Keith J MurphyCiaran M Regan
Jul 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chad A BousmanIan P Everall
Mar 24, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Donald C GoffSteven G Potkin
Sep 8, 2010·Developmental Disabilities Research Reviews·Fernando Scaglia
Sep 10, 2014·Proteomics. Clinical Applications·Sarah PlumCaroline May
Oct 16, 2014·Annals of the New York Academy of Sciences·Wei HuRobert A Sweet
Feb 3, 2015·Genes, Brain, and Behavior·S ChandrasekaranG E Robinson
Dec 1, 2004·Drug Discovery Today. Technologies·Julian L Griffin
May 19, 2009·Biochemical Pharmacology·Hanit Brenner-LavieDorit Ben-Shachar
Oct 5, 2010·Biological Psychiatry·Jane A EnglishD R Cotter
Sep 26, 2006·Biological Psychiatry·Barbara K LipskaJoel E Kleinman
Sep 26, 2006·Biological Psychiatry·Christine E MarxJeffrey A Lieberman
Nov 29, 2015·Neurologic Clinics·Samantha E Marin, Russell P Saneto
Aug 30, 2006·Brain Research·Elizabeth O'BrienIzuru Matsumoto
Jun 13, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Abha Chauhan, Ved Chauhan
Apr 21, 2006·Schizophrenia Research·Jianfeng MeiBarbara Porton
Apr 25, 2006·Schizophrenia Research·Rainald Schmidt-KastnerChristoph Schmitz
Apr 2, 2016·Journal of Molecular Neuroscience : MN·Cécile MonpaysSylvain Grignon
Feb 1, 2006·Neuroscience and Biobehavioral Reviews·L Alison McInnes, Tara L Lauriat
Dec 6, 2005·Brain Research Reviews·Joana Almeida Palha, A B Goodman
Jul 12, 2005·Schizophrenia Research·Hans-Gert BernsteinGerburg Keilhoff
Jan 24, 2012·Schizophrenia Research·Mark S MoehleRobert E McCullumsmith
Aug 20, 2015·Schizophrenia Research·Aurélie BergonEl Chérif Ibrahim
Jan 19, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Joanna Kałużna-Czaplińska, Jagoda Jóźwik-Pruska
Dec 19, 2015·Proteomics. Clinical Applications·Juliana S CassoliDaniel Martins-de-Souza
Mar 12, 2015·Psychiatry and Clinical Neurosciences·Chenyao WangNorio Ozaki
Jul 16, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Toru NakamuraHeii Arai
Jan 27, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Marc-Emmanuel Dumas, Laetitia Davidovic
Jun 20, 2012·Frontiers in Neuroendocrinology·John O'Kusky, Ping Ye
Dec 4, 2014·Schizophrenia Research·Meng XiaMikhail Pletnikov
Sep 18, 2013·Psychiatry Research·Marija BoškovićTomaž Vovk
Oct 23, 2012·Psychoneuroendocrinology·L W HarrisSabine Bahn
May 23, 2014·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Byung Dae LeeHyo Deog Rim
Dec 3, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P BubberJ P Blass
Feb 1, 2011·Neuropharmacology·Kazu NakazawaJuan E Belforte
Oct 28, 2011·Molecular Genetics and Metabolism·Tomoe IchikawaMasanari Itokawa
Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tohru Ohnuma, Heii Arai
Jun 21, 2015·Neuroscience and Biobehavioral Reviews·Juan C LezaMiguel Bernardo
May 15, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yan RenYong Xu
Apr 30, 2015·European Journal of Cell Biology·Hyoeun McDermott, Kyoungtae Kim
Dec 3, 2014·Schizophrenia Research·Sheila Seybolt
Jun 20, 2008·Schizophrenia Research·Amy E SteffekJames H Meador-Woodruff
Apr 22, 2011·Medical Hypotheses·Mahabaleshwar V Hegde, Arundhati A Saraph
Mar 15, 2011·Neurobiology of Disease·P Adolfo SequeiraMarquis P Vawter
Mar 24, 2009·Neurobiology of Disease·Marlon P Quinones, Rima Kaddurah-Daouk
Jul 12, 2011·Neuroscience Letters·L P FrancesconiP Belmonte-de-Abreu
Jun 2, 2009·Current Opinion in Neurobiology·Kim Q DoM Cuenod
May 30, 2012·Journal of Proteomics·Julian A J JarosSabine Bahn
Oct 27, 2010·Neuroscience and Biobehavioral Reviews·Byron K Y Bitanihirwe, Tsung-Ung W Woo
Aug 31, 2010·Journal of Neuroscience Methods·Eliza CourtneyMichal Janitz
Feb 1, 2011·Journal of Affective Disorders·M BerkOttar Bjerkeset
Aug 23, 2011·Neuropharmacology·S Berretta
Jul 22, 2014·Asian Journal of Psychiatry·Venkataram ShivakumarBangalore N Gangadhar
Mar 6, 2008·American Journal of Human Genetics·Jonathan MillArturas Petronis
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Ashwini RajasekaranMonojit Debnath
Jun 3, 2016·Frontiers in Physiology·Catherine G VasilopoulouMaria I Klapa
Jul 28, 2016·Journal of Pharmaceutical and Biomedical Analysis·Carolina Gonzalez-RianoCoral Barbas
Aug 20, 2016·Drug Development Research·Miroslav AdzicMarija B Radojcic
Apr 27, 2016·Cytoskeleton·Francesca MarchisellaPatrik Hollos
Nov 9, 2016·Neurotoxicology·Djai B Heyer, Rhiannon M Meredith
Jan 23, 2016·PloS One·Yiting ZhangRichard C Deth
Jan 10, 2017·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Yanfei Zhang, José L Avalos
Nov 13, 2015·Genes, Brain, and Behavior·S A Schoenrock, Lisa M Tarantino
May 17, 2012·Schizophrenia Bulletin·Stefan SmesnyJoachim W Fluhr
Dec 1, 2017·Briefings in Bioinformatics·Jessica D TenenbaumLeon Rozenblit
Mar 16, 2006·European Journal of Human Genetics : EJHG·L MartorellE Vilella
Jul 21, 2004·Molecular Psychiatry·P J Harrison, D R Weinberger
Aug 8, 2013·International Journal of Tryptophan Research : IJTR·Musthafa Mohamed EssaGilles J Guillemin
Jan 10, 2018·Frontiers in Cellular and Infection Microbiology·Genevieve SynSarra E Jamieson
Dec 19, 2017·Translational Psychiatry·Han CaoE Schwarz
Jun 19, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephan ZüchnerJean C Beckham
Apr 24, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Jacob T BjerrumJørgen Olsen
Jul 25, 2018·International Journal of Molecular Sciences·Hung NguyenCesar V Borlongan
Jun 24, 2006·Circulation Research·Andrey MorgunMaria Gerbase-DeLima
Jun 22, 2006·European Child & Adolescent Psychiatry·Claudia Mehler-WexManfred Gerlach
Jun 22, 2005·Expert Review of Proteomics·K Lilley, David B Friedman
Oct 13, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nagafumi Doi, Yoko Hoshi
Oct 27, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nagafumi DoiTakeo Yoshikawa
Jan 25, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ayda TavitianHyman M Schipper
Aug 4, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Emilio L StreckJoão Quevedo
Apr 28, 2005·The Journal of Biological Chemistry·Alexandra LafayeJean Labarre
Jan 24, 2009·European Archives of Psychiatry and Clinical Neuroscience·Daniel Martins-de-SouzaChristoph W Turck
Mar 3, 2018·Molecular Psychiatry·Courtney R SullivanRobert E McCullumsmith
Mar 16, 2019·Annals of the New York Academy of Sciences·M Catarina Silva, Stephen J Haggarty
Feb 24, 2006·Molecular Psychiatry·D ClarkIzuru Matsumoto
Mar 2, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shinsuke WashizukaTadafumi Kato
Mar 24, 2006·Electrophoresis·Michael Fountoulakis, Sophia Kossida
Aug 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hendrik WesselingSabine Bahn
Oct 5, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E McCullumsmithJames H Meador-Woodruff
Nov 8, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa F GonçalvesJames L Kennedy
Oct 17, 2009·Journal of Human Genetics·Tearina T ChuEileen Kemether
Apr 13, 2011·Molecular Psychiatry·E SchwarzSabine Bahn
Jun 17, 2015·Molecular Psychiatry·T T QuachA M Duchemin
Oct 11, 2007·Molecular Psychiatry·G KaroutzouD E Dietrich
Aug 21, 2009·Nature Reviews. Neuroscience·Alex Bayés, Seth G N Grant
Nov 30, 2016·Translational Psychiatry·Laura M RowlandP B Barker
Mar 24, 2016·Scientific Reports·Kirstie A Cummings, Gabriela K Popescu
May 6, 2019·The American Journal of Psychiatry·Leslie G NuciforaFrederick C Nucifora
Mar 20, 2008·Molecular & Cellular Proteomics : MCP·Rachel M CraddockSabine Bahn
Oct 18, 2008·Physiology·Tamer Rabie, Hugo H Marti
Aug 5, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hideo HagiharaTsuyoshi Miyakawa
Jan 1, 2015·NPJ Schizophrenia·Juliana M Nascimento, Daniel Martins-de-Souza
Jan 22, 2010·The Protein Journal·Giuseppina MaccarroneDaniel Martins-de-Souza
Nov 23, 2019·Schizophrenia Bulletin·Federico E TurkheimerAnthony C Vernon
Nov 13, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Jun 16, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jenna R GaleBarry B Kaplan
Oct 26, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·B M NilssonA H Forslund
Oct 29, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·B VergeL Martorell
Apr 28, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peiyan Ni, Sangmi Chung
Dec 19, 2019·Antioxidants & Redox Signaling·Ayda TavitianHyman M Schipper
Aug 17, 2016·Oxidative Medicine and Cellular Longevity·Kärt KriisaMihkel Zilmer
Nov 16, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Tanja Maria MichelPeter Riederer
Jun 14, 2020·International Journal of Molecular Sciences·Julia PanovHanoch Kaphzan
Jun 5, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Bing CaoJingyu Wang
Jul 18, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dongfang WangBing Cao
Sep 4, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miho OtaHiroshi Kunugi
Aug 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Shahza M SomervilleRosalinda C Roberts
Sep 23, 2017·Frontiers in Neuroscience·Giuliana S ZuccoliDaniel Martins-de-Souza
Mar 6, 2019·Frontiers in Psychiatry·Christina BoeckIris-Tatjana Kolassa
Jun 14, 2019·Current Opinion in Psychiatry·Zoltán SarnyaiChristopher M Palmer
May 28, 2020·Journal of Clinical Medicine·Lilach SimchiHanoch Kaphzan
Jul 1, 2020·Current Behavioral Neuroscience Reports·Maju Mathew KoolaAnilkumar Pillai
Aug 28, 2020·Anais Da Academia Brasileira De Ciências·Cristiane M L DE MeloAntÔnio C DE Freitas
Feb 1, 2013·Acta Neuropsychiatrica·Giselli ScainiEmilio L Streck
Jun 2, 2018·Neural Plasticity·Ulfuara ShefaJunyang Jung
Aug 27, 2017·Neurotoxicity Research·Justyna BrodowiczMalgorzata Filip
Oct 5, 2018·Journal of Biomedical Science·Yu-Ting WengYijuang Chern
Dec 12, 2018·Molecular Psychiatry·Oded BergmanDorit Ben-Shachar
Jan 29, 2019·Frontiers in Psychiatry·Carsten CulmseeJudith Alferink
Mar 27, 2019·Scientific Reports·Courtney R SullivanRobert E McCullumsmith
Sep 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kazuki TeradaYoshiharu Karube
Aug 28, 2020·Frontiers in Neuroscience·Marissa R KeeverSandra L Rodriguez-Zas
Aug 12, 2008·Journal of Separation Science·Daniel Martins-de-SouzaChristoph W Turck
Feb 1, 2007·Proteomics. Clinical Applications·Danielle ClarkIzuru Matsumoto
Oct 5, 2016·Journal of Clinical Biochemistry and Nutrition·Manatsu KurajiTazuko Satoh
Oct 14, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O K SavushkinaG Sh Burbaeva
Jul 13, 2018·Molecular Neuropsychiatry·Dimitrios Avramopoulos
Jul 13, 2018·Molecular Neuropsychiatry·Ari B CuperfainVanessa F Gonçalves
Apr 26, 2019·Frontiers in Psychiatry·Shibani DhirCecilia Giulivi
Jan 11, 2020·Frontiers in Psychiatry·Ashutosh KumarPavan Kumar
Aug 22, 2020·Therapeutic Advances in Neurological Disorders·Idris Janos JimohMaria Judit Molnar
Apr 20, 2018·Scientific Reports·Tania Da SilvaRomina Mizrahi
Nov 25, 2018·Translational Psychiatry·Sophie HackingerEleftheria Zeggini
Jul 6, 2020·Lipids in Health and Disease·Mei-Chi HsuWen-Chen Ouyang
Jul 30, 2016·Glia·Giulia PoggiHannelore Ehrenreich
Mar 20, 2009·The Australian and New Zealand Journal of Psychiatry·Maryam NesvaderaniSinthuja Sivagnanasundaram
Nov 12, 2020·Journal of Psychopharmacology·Ari Brouwer, Robin Lester Carhart-Harris
Jan 5, 2021·Pharmacological Reports : PR·Cinara Ludvig GonçalvesGislaine Zilli Réus
Jan 8, 2021·Neurochemical Research·Xiaolu ZhangSinead M O'Donovan
Jan 12, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Leszek RudzkiAgata Szulc
Oct 21, 2017·Journal of Clinical Psychopharmacology·Lia Lira Olivier SandersDavid Freitas de Lucena
Sep 28, 2020·Computers in Biology and Medicine·S T R Moolamalla, P K Vinod
Nov 21, 2019·Schizophrenia Research·Shawna T ChanMarquis P Vawter
Aug 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shaista Chaudhary, Suhel Parvez
Dec 6, 2020·International Journal of Molecular Sciences·Behnaz KhavariMurray J Cairns
Feb 9, 2021·Oxidative Medicine and Cellular Longevity·Evgeny A ErmakovLiudmila P Smirnova

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