Mitochondrial Dysfunction in Schizophrenia

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Peiyan Ni, Sangmi Chung


Schizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations worldwide with a grave disability and socioeconomic burden. Current antipsychotic medications are effective treatments for positive symptoms, but poorly address negative symptoms and cognitive symptoms, warranting the development of better treatment options. Further understanding of SCZ pathogenesis is critical in these endeavors. Accumulating evidence has pointed to the role of mitochondria and metabolic dysregulation in SCZ pathogenesis. This review critically summarizes recent studies associating a compromised mitochondrial function with people with SCZ, including postmortem studies, imaging studies, genetic studies, and induced pluripotent stem cell studies. This review also discusses animal models with mitochondrial dysfunction resulting in SCZ-relevant neurobehavioral abnormalities, as well as restoration of mitochondrial function as potential therapeutic targets. Further understanding of mitochondrial dysfunction in SCZ may open the door to develop novel therapeutic strategies that can address the symptoms that cannot be adequately addressed by current antipsychotics alone.


Apr 9, 1981·Nature·Stewart A AndersonI G Young
Nov 1, 1994·Biochemical Society Transactions·K KatsuraB K Siesjö
Aug 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J A PrinceL Oreland
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tory M HagenBruce N Ames
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaTibor Farkas
Nov 8, 2002·International Review of Neurobiology·John P Blass
Mar 25, 2004·Biological Psychiatry·Rachel KarryDorit Ben Shachar
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaLászló G Puskás
Mar 24, 2005·The International Journal of Neuropsychopharmacology·Neil D WoodwardDavid H Zald
Mar 16, 2006·European Journal of Human Genetics : EJHG·Lourdes MartorellElisabet Vilella
May 12, 2006·Journal of Cardiovascular Electrophysiology·Masayasu Hiraoka
Sep 20, 2006·The Journal of Biological Chemistry·Gema B MontalvoJuan A Gilabert
Mar 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dorit Ben-ShacharNanette Freedman
Apr 23, 2008·Annals of Medicine·Ling ShaoMarquis P Vawter
Jan 24, 2009·Biochimica Et Biophysica Acta·Nicolas DemaurexMaud Frieden
Feb 5, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·David M OtteAndreas Zimmer
Jul 1, 2009·Mitochondrion·Hitomi UenoMasashi Tanaka
Aug 12, 2009·Biochimica Et Biophysica Acta·Kate Petersen ShayTory M Hagen
May 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K A BarksdaleGautam N Bijur
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth K LucasRita M Cowell
Jul 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David-Marian OtteAndreas Zimmer
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bita Moghaddam, Daniel Javitt
Jun 23, 2012·Frontiers in Genetics·Adolfo SequeiraMarquis P Vawter
Mar 21, 2013·Nature Reviews. Neuroscience·Gordon M G Shepherd
Apr 2, 2014·Molecular Psychiatry·Kristen J BrennandFred H Gage
Apr 30, 2014·Molecular Psychiatry·Jin P SzatkiewiczPatrick F Sullivan
Jun 5, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Oliver KannAndreas Draguhn
Jun 29, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sarah AfshordelGunter P Eckert
Jul 25, 2014·Nature·Schizophrenia Working Group of the Psychiatric Genomics Consortium
Aug 1, 2014·Behavioural Brain Research·Davide Amato
Aug 19, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Helena TorrellLourdes Martorell
Oct 2, 2014·Schizophrenia Research·Firoza MamdaniMarquis P Vawter
Oct 8, 2014·Translational Psychiatry·Yunjung KimPatrick F Sullivan
Oct 15, 2014·Nature Reviews. Neurology·Irene KnueselEric P Prinssen
Dec 4, 2014·The Journal of Clinical Psychiatry·Anissa Abi-Dargham
Apr 18, 2015·PLoS Computational Biology·Christiaan A de LeeuwDanielle Posthuma
May 10, 2015·British Medical Bulletin·John Lally, James H MacCabe
Aug 12, 2015·Nature Communications·G P AmmingerP D McGorry
Sep 24, 2015·Anais Da Academia Brasileira De Ciências·Alexandra I ZugnoClarissa S Gama
Nov 10, 2015·Molecular Neuropsychiatry·Brooke E HjelmMarquis P Vawter
Jan 29, 2016·Current Pharmaceutical Design·Andrew Gibbons, Brian Dean
May 4, 2016·The Journal of Clinical Psychiatry·Brisa S FernandesM Berk
Jan 1, 2015·Nature Reviews. Disease Primers·René S KahnThomas R Insel
Jun 17, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Alencar Kolinski MachadoAna Cristina Andreazza
Jul 5, 2016·Current Treatment Options in Psychiatry·Gary RemingtonMargaret Hahn
Jul 15, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Oded Bergman, Dorit Ben-Shachar
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alaa El-Sayed El-SisiEnass Yossef Osman
Aug 20, 2016·Science·Myka L Estes, A Kimberley McAllister
Sep 25, 2016·Schizophrenia Bulletin·Sang-Young KimDost Öngür
Oct 11, 2016·Biological Psychiatry·Oliver D HowesRobin M Murray
Nov 22, 2016·Nature Genetics·Christian R MarshallCNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium
Nov 30, 2016·Psychological Medicine·M Rapado-CastroO M Dean
Jan 11, 2017·International Review of Cell and Molecular Biology·S PatergnaniP Pinton
Feb 10, 2017·Schizophrenia Research·Jill R Glausier, D A Lewis
Feb 18, 2017·The Journal of Cell Biology·Taiichi TsuyamaTadashi Uemura
Jun 15, 2017·JAMA Psychiatry·Douglas C Wallace
Jun 22, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Arvin HaghighatfardZakieh Ghadimi
Aug 5, 2017·International Journal of Molecular Sciences·Albert C Yang, Shih-Jen Tsai
Aug 24, 2017·Schizophrenia Research·Yi QiaoBin Long
Sep 23, 2017·Frontiers in Neuroscience·Giuliana S ZuccoliDaniel Martins-de-Souza
Oct 19, 2017·Schizophrenia Bulletin·Daniel R Weinberger
Oct 21, 2017·Journal of Clinical Psychopharmacology·Lia Lira Olivier SandersDavid Freitas de Lucena
Nov 8, 2017·Molecular Psychiatry·J F Enwright IiiD A Lewis
Nov 11, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Trude Seselie Jahr IversenErik G Jönsson
Nov 12, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zahra SepehrmaneshMahshid Heidary
Dec 9, 2017·Biological Psychiatry·Courtney R SullivanAmy J Ramsey
Feb 17, 2018·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Giselli ScainiConsuelo Walss-Bass
Mar 3, 2018·Molecular Psychiatry·Courtney R SullivanRobert E McCullumsmith
Apr 10, 2018·Biological Psychiatry·Vanessa GoncalvesLei Sun
Apr 13, 2018·Translational Psychiatry·Yan JouroukhinMikhail Pletnikov
Jul 13, 2018·Molecular Neuropsychiatry·Ari B CuperfainVanessa Goncalves
Mar 27, 2019·Scientific Reports·Courtney R SullivanRobert E McCullumsmith
Apr 26, 2019·Molecular Neuropsychiatry·Anton SchulmannMarquis P Vawter
May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Sinan GuloksuzJim van Os
May 14, 2019·Neuron·Alejandra FernandezAnthony-Samuel LaMantia
May 23, 2019·Schizophrenia Research·Daniel J LeirerStephen J Newhouse
Jun 21, 2019·Neuron·Emily B Warren, Eric M Morrow

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