Mitochondrial dysfunction in titanium dioxide nanoparticle-induced neurotoxicity

Toxicology Mechanisms and Methods
Nandini Nalika, Suhel Parvez

Abstract

Nanotechnology has emerged as a field of scientific innovation which has opened up a plethora of concerns for the potential impact on human and environment. Various toxicological studies have confirmed that nanoparticles (NPs) can be potentially hazardous because of their unique small size and physico-chemical properties. With the wide applications of titanium dioxide nanoparticles (TNPs) in day-to-day life in form of cosmetics, paints, sterilization and so on, there is growing concern regarding the deleterious effects of TNPs on central nervous system. Mitochondria is an important origin for generation of energy as well as free radicals and these free radicals can lead to mitochondrial damage and finally lead to apoptosis. The objective of our study was to elucidate the potential neurotoxic effect of TNPs in anatase form. Oxidative stress was determined by measuring lipid peroxidation and protein carbonyl content which was found to be significantly increased. Reduced glutathione content and major glutathione metabolizing enzymes were also modulated signifying the role of glutathione redox cycle in the pathophysiology of TNPs. Mitochondrial complexes were also modulated from the exposure to TNPs. The present study indicates tha...Continue Reading

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Citations

Jun 15, 2016·Nanoscale Research Letters·Bin SongLongQuan Shao
Aug 11, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Niyou WangA Senthil Kumar
Aug 12, 2016·The Journal of Membrane Biology·Lu LaiYi Liu
Sep 12, 2019·Chemico-biological Interactions·Keywan MortezaeeAmirhossein Ahmadi

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