Mitochondrial dysfunction is a common phenotype in aging and cancer

Annals of the New York Academy of Sciences
Keshav K Singh

Abstract

An interesting clue with regard to molecular mechanisms underlying age-associated cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a progressive decline in mitochondrial function during aging. Studies have established that the decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis.

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Citations

Jun 7, 2007·Journal of Bioenergetics and Biomembranes·Zhao ChenPeng Huang
Jul 8, 2010·In Vitro Cellular & Developmental Biology. Animal·Sudhakar BaluchamyGovindarajan T Ramesh
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Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Pierre S HaddadMichel Boivin
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Jun 2, 2011·Cold Spring Harbor Perspectives in Biology·Michael J BakerThomas Langer
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Liang WangStephen N Thibodeau
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Jan 8, 2013·Archives of Medical Research·Behnam Kamalidehghan, Massoud Houshmand
Dec 29, 2007·Biochemical and Biophysical Research Communications·Xu-Jun QinChun-Xu Hai
Jun 29, 2006·Annals of the New York Academy of Sciences·Keshav K Singh
Nov 19, 2005·DNA Repair·Ratsavarinh VongsamphanhDindial Ramotar
Jul 30, 2005·Mitochondrion·David MeierhoferBarbara Kofler
Mar 24, 2012·Computers in Biology and Medicine·Xue XiaoZhicheng Liu
Nov 16, 2010·Biochimica Et Biophysica Acta·Dhyan Chandra, Keshav K Singh
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Aug 29, 2006·Human Reproduction Update·C Allegrucci, L E Young

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