Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

The Journal of Clinical Investigation
Charlotte BonnardJennifer Rieusset

Abstract

Mitochondrial dysfunction in skeletal muscle has been implicated in the development of type 2 diabetes. However, whether these changes are a cause or a consequence of insulin resistance is not clear. We investigated the structure and function of muscle mitochondria during the development of insulin resistance and progression to diabetes in mice fed a high-fat, high-sucrose diet. Although 1 month of high-fat, high-sucrose diet feeding was sufficient to induce glucose intolerance, mice showed no evidence of mitochondrial dysfunction at this stage. However, an extended diet intervention induced a diabetic state in which we observed altered mitochondrial biogenesis, structure, and function in muscle tissue. We assessed the role of oxidative stress in the development of these mitochondrial abnormalities and found that diet-induced diabetic mice had an increase in ROS production in skeletal muscle. In addition, ROS production was associated with mitochondrial alterations in the muscle of hyperglycemic streptozotocin-treated mice, and normalization of glycemia or antioxidant treatment decreased muscle ROS production and restored mitochondrial integrity. Glucose- or lipid-induced ROS production resulted in mitochondrial alterations in ...Continue Reading

References

Jun 28, 2002·Nucleic Acids Research·Maria A GraziewiczWilliam C Copeland
Sep 28, 2002·Diabetes·David E KelleyVladimir B Ritov
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James W RussellEva L Feldman
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mary Elizabeth PattiLawrence J Mandarino
Jul 17, 2003·Acta Physiologica Scandinavica·B D HegartyE W Kraegen
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
Apr 14, 2004·Current Medicinal Chemistry·M Krebs, M Roden
May 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arend BonenDavid J Dyck
Aug 6, 2004·The Proceedings of the Nutrition Society·Patrick Schrauwen, Matthijs K C Hesselink
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Jun 9, 2005·The Tohoku Journal of Experimental Medicine·Selim KutluGiyasettin Baydas
Jul 7, 2005·Antioxidants & Redox Signaling·Joseph L EvansIra D Goldfine
Feb 9, 2006·Chemical Reviews·Maria A GraziewiczWilliam C Copeland
Mar 9, 2007·The Proceedings of the Nutrition Society·Patrick Schrauwen
Mar 10, 2007·The EMBO Journal·Zachary Gerhart-HinesPere Puigserver

❮ Previous
Next ❯

Citations

Oct 13, 2009·Journal of Inherited Metabolic Disease·M SchiffP Rustin
Sep 13, 2012·Journal of Bioenergetics and Biomembranes·Jie QiuXi-Rong Guo
Oct 23, 2010·Current Hypertension Reports·Vanina Romanello, Marco Sandri
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kyle L HoehnDavid E James
Mar 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·David SebastiánAntonio Zorzano
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michele CarrerEric N Olson
Dec 17, 2008·Antioxidants & Redox Signaling·Andrea M VincentEva L Feldman
Jun 4, 2010·Antioxidants & Redox Signaling·Yisang YoonTianzheng Yu
Jun 29, 2010·Antioxidants & Redox Signaling·Asokan DevarajanSrinivasa T Reddy
Feb 28, 2009·Acta Physiologica·B D HegartyE W Kraegen
Nov 16, 2011·Molecular and Cellular Biology·Huei-Fen JhengYau-Sheng Tsai
Jun 18, 2009·American Journal of Physiology. Endocrinology and Metabolism·Louis Hue, Heinrich Taegtmeyer
Mar 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christine RuggieroKrisztian Stadler
Nov 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael J RaherMarielle Scherrer-Crosbie
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Scott D ZawiejaMariappan Muthuchamy
Jul 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret J R HeerwagenJacob E Friedman
May 23, 2012·International Journal of Vascular Medicine·Gopi Krishna KolluruChristopher G Kevil
Feb 21, 2009·American Journal of Nephrology·E Matthew MorrisJames R Sowers
Jun 25, 2008·Hypertension·Romain HarmanceyHeinrich Taegtmeyer
Sep 5, 2008·The Journal of Clinical Investigation·Simon SchenkJerrold M Olefsky
Feb 4, 2009·The Journal of Clinical Investigation·Ethan J AndersonP Darrell Neufer
Nov 19, 2009·The Journal of Clinical Investigation·Rachel J RothAnton M Bennett
May 11, 2011·The Journal of Clinical Investigation·Alison SleighDavid B Savage
Jun 12, 2012·Nutrition & Metabolism·Rita Rinnankoski-TuikkaHeikki Kainulainen
Aug 30, 2012·BMC Systems Biology·Anja KarlstädtHermann-Georg Holzhütter

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
electron microscopy
acetylation
ELISA
PCR
electrophoresis
FCS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.