Mitochondrial Dysfunctions in Type I Endometrial Carcinoma: Exploring Their Role in Oncogenesis and Tumor Progression

International Journal of Molecular Sciences
Clara MusiccoAntonella Cormio

Abstract

Type I endometrial cancer (EC) is the most common form of EC, displaying less aggressive behavior than type II. The development of type I endometrial cancer is considered a multistep process, with slow progression from normal endometrium to hyperplasia, the premalignant form, and endometrial cancer as a result of an unopposed estrogenic stimulation. The role of mitochondria in type I EC tumor progression and prognosis is currently emerging. This review aims to explore mitochondrial alterations in this cancer and in endometrial hyperplasia focusing on mitochondrial DNA mutations, respiratory complex I deficiency, and the activation of mitochondrial quality control systems. A deeper understanding of altered mitochondrial pathways in type I EC could provide novel opportunities to discover new diagnostic and prognostic markers as well as potential therapeutic targets.

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Citations

Mar 19, 2020·Cancers·Li ZhangSamuel C Mok
Nov 16, 2018·Cellular and Molecular Life Sciences : CMLS·Luiz Gustavo de Almeida ChuffaLuiz Antonio Lupi
Jun 18, 2020·Reproductive Sciences·Tadahi OkadaTakashi Kojima
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May 29, 2021·Nature Reviews. Cancer·Piotr K KopinskiDouglas C Wallace

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Methods Mentioned

BETA
protein folding
Electrophoresis
laser-capture microdissection

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