Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity

Biomaterials
Chengyong HeGang Liu

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are highly cytotoxic and target cancer cells with high specificity; however, the mechanism by which SPIONs induce cancer cell-specific cytotoxicity remains unclear. Herein, the molecular mechanism of SPION-induced cancer cell-specific cytotoxicity to cancer cells is clarified through DNA microarray and bioinformatics analyses. SPIONs can interference with the mitochondrial electron transport chain (METC) in cancer cells, which further affects the production of ATP, mitochondrial membrane potential, and microdistribution of calcium, and induces cell apoptosis. Additionally, SPIONs induce the formation of reactive oxygen species in mitochondria; these reactive oxygen species trigger cancer-specific cytotoxicity due to the lower antioxidative capacity of cancer cells. Moreover, the DNA microarray and gene ontology analyses revealed that SPIONs elevate the expression of metallothioneins in both normal and cancer cells but decrease the expression of METC genes in cancer cells. Overall, these results suggest that SPIONs induce cancer cell death by targeting the METC, which is helpful for designing anti-cancer nanotheranostics and evaluating the safety of future nanomedicines.

References

Nov 1, 2005·Nature Biotechnology·I Jolanda M de VriesCarl G Figdor
Jul 2, 2008·Drug Discovery Today. Disease Models·Weiqin LuPeng Huang
May 30, 2009·Nature Reviews. Drug Discovery·Dunyaporn TrachoothamPeng Huang
Jan 29, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Ya-Na WuDar-Bin Shieh
Mar 23, 2011·The Journal of Pharmacology and Experimental Therapeutics·Kenjirou HaraMasayasu Inoue
Apr 5, 2011·Cell·Maria Eugenia Soriano, Luca Scorrano
May 10, 2011·Accounts of Chemical Research·Jin XieXiaoyuan Chen
Jul 12, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hongyou ZhaoQun Chen
Jan 31, 2012·Biochimica Et Biophysica Acta·Caiyong Chen, Barry H Paw
Apr 26, 2013·Stem Cells and Development·Jaime DeSantiagoKathrin Banach
Jun 12, 2013·Chemical Communications : Chem Comm·Wei-Hai ChenXian-Zheng Zhang
Jul 3, 2013·Science·Esther Lapuente-BrunJosé Antonio Enríquez
Aug 3, 2013·Cold Spring Harbor Perspectives in Biology·Oliver Stehling, Roland Lill
Jul 12, 2014·The Journal of Biological Chemistry·Jihoon RyuRenu Wadhwa
Aug 3, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eun-Jung ParkSang-Wook Kim
Dec 3, 2014·Current Opinion in Microbiology·Roland LillUlrich Mühlenhoff

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Citations

Jul 12, 2019·Journal of Applied Toxicology : JAT·Na Liu, Meng Tang
Mar 28, 2017·Chinese Medical Journal·Dong-Mei Zou, Wan-Ling Sun
Feb 23, 2019·Materials·Joanna Dulińska-LitewkaAnna Karewicz
May 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Caixia YangGang Liu
Mar 8, 2020·Antioxidants·Francesco CiccareseVincenzo Ciminale
Nov 24, 2020·3 Biotech·Jaison JeevanandamMichael K Danquah
Feb 13, 2021·Cell Chemical Biology·Louis P ConwayChristopher G Parker
Nov 26, 2019·Current Medicinal Chemistry·Olakunle OladimejiMoganavelli Singh
Aug 30, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adam FrtúsOleg Lunov
Dec 2, 2020·Journal of Hazardous Materials·Fengkai RuanYongxing Zhang
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
May 15, 2021·Frontiers in Chemistry·Shancheng YuHaiming Fan
Mar 27, 2020·Bioconjugate Chemistry·Sukanya SrijampaPatcharaporn Tippayawat

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