Mitochondrial enzyme content in the muscles of high-performance fish: evolution and variation among fiber types

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Anne C DalzielChristopher D Moyes

Abstract

Muscle mitochondrial content varies widely among fiber types and species. We investigated the origins of variation in the activity of the mitochondrial enzyme citrate synthase (CS), an index of mitochondrial abundance, among fiber types and species of high-performance fish (tunas and billfishes). CS activities varied up to 30-fold among muscles: lowest in billfish white muscle and highest in billfish heater organ. Among species, CS activities of red, white, and cardiac muscles of three tuna species were twofold greater than the homologous muscles of two billfish species. Because comparisons of CS amino acid sequences deduced from a combination of PCR methods argue against clade-specific differences in catalytic properties, CS activity reflects CS content among these five species. To assess the bases of these differences in CS activity, we looked at the relationship between CS activity (U/g muscle), nuclear content (DNA/g muscle), and CS transcript levels (CS mRNA/g RNA). Muscle CS activity differed by 10- to 30-fold when expressed per gram of muscle but only threefold when expressed per milligram of DNA. Thus it is nuclear DNA content, not fiber-type differences, in CS gene expression that may be the main determinant of CS acti...Continue Reading

References

Jan 1, 1992·Current Topics in Cellular Regulation·S J Remington
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·G Wiegand, S J Remington
Sep 1, 1988·The Journal of Cell Biology·B A Block, C Franzini-Armstrong
May 1, 1985·Pflügers Archiv : European journal of physiology·H ReichmannD Pette
Jan 1, 1982·Cell and Tissue Research·K S BuserH Hoppeler
Feb 25, 1993·Nucleic Acids Research·F S CeliA R Shuldiner
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·N K GrayM W Hentze
Aug 1, 1996·BioTechniques·F SouazéP Forgez
Apr 1, 1997·The American Journal of Physiology·C D MoyesR G Hansford
Sep 5, 1998·The American Journal of Physiology·B J Battersby, C D Moyes
Nov 11, 1998·Genome Génome / Conseil National De Recherches Canada·M J GoldenthalR Ananthakrishnan
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Oct 6, 2000·The Journal of Clinical Investigation·J J LehmanD P Kelly
Feb 13, 2001·Molecular Phylogenetics and Evolution·L I GrossmanM Goodman
Apr 16, 2002·Science·Hai WuR Sanders Williams
May 29, 2002·Biochimica Et Biophysica Acta·Richard C Scarpulla
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·S C LearyC D Moyes
Jan 14, 2003·Annual Review of Physiology·Christopher D Moyes, David A Hood
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael P CzubrytEric N Olson
Apr 4, 2003·Current Opinion in Genetics & Development·Cheryl C Hsia, William McGinnis
May 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christoph HandschinBruce M Spiegelman
Jun 5, 2003·Molecular Biology and Evolution·Gregory A WrayLaura A Romano
Aug 5, 2003·Genome Génome / Conseil National De Recherches Canada·David C Hardie, Paul D N Hebert
Aug 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M LucassenH-O Pörtner
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael A Resnick, Alberto Inga
Aug 30, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S C LearyC D Moyes
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bartosz SzczesnyIstvan Boldogh
Nov 12, 2003·The Journal of Experimental Biology·Christopher D Moyes
Aug 1, 1992·Fish Physiology and Biochemistry·E Don Stevens

❮ Previous
Next ❯

Citations

Jul 6, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Anneli StrobelFelix C Mark
Jul 27, 2018·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Giorgio Gabella
Dec 10, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Yanlu LiXiangdi Kong
Feb 16, 2006·Journal of Molecular Evolution·Anne C DalzielStephen C Lougheed
Jan 21, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Chao ChenXiangdi Kong
Jan 21, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Yanlu LiXiangdi Kong
May 29, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Hui Zhang, Weiwei Xian
Jun 27, 2012·Exercise and Sport Sciences Reviews·Grant B McClelland
Dec 20, 2008·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sophie BretonPierre U Blier
May 19, 2011·Physiological Genomics·K M KochaC D Moyes
Oct 21, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Hui Zhang, Weiwei Xian
Aug 19, 2010·Physiological Genomics·Aivaras RatkeviciusArimantas Lionikas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.