Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases

Journal of Bioenergetics and Biomembranes
G E Gibson, Hsueh-Meei Huang

Abstract

Considerable evidence indicates that oxidative stress accompanies age-related neurodegenerative diseases. Specific mechanisms by which oxidative stress leads to neurodegeneration are unknown. Two targets of oxidative stress that are known to change in neurodegenerative diseases are the mitochondrial enzyme alpha-ketoglutarate dehydrogenase complex (KGDHC) and endoplasmic reticulum calcium stores. KGDHC activities are diminished in all common neurodegenerative diseases and the changes are particularly well documented in Alzheimer's disease (AD). A second change that occurs in cells from AD patients is an exaggerated endoplasmic reticulum calcium store [i.e., bombesin-releasable calcium stores (BRCS)]. H(2)O(2), a general oxidant, changes both variables in the same direction as occurs in disease. Other oxidants selectively alter these variables. Various antioxidants were used to help define the critical oxidant species that modifies these responses. All of the antioxidants diminish the oxidant-induced carboxy-dichlorofluorescein (cDCF) detectable reactive oxygen species (ROS), but have diverse actions on these cellular processes. For example, alpha-keto-beta-methyl-n-valeric acid (KMV) diminishes the H(2)O(2) effects on BRCS, whi...Continue Reading

Citations

Apr 2, 2011·The Journal of Biological Chemistry·Qingli ShiGary E Gibson
Oct 13, 2006·Antioxidants & Redox Signaling·Mark P Mattson
Aug 13, 2010·Antioxidants & Redox Signaling·Marioly MüllerJ Kevin Foskett
May 24, 2007·Journal of Neurotrauma·Wycliffe O OpiiD Allan Butterfield
Jul 4, 2012·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalSajal Gupta
Jul 16, 2005·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalRakesh K Sharma
Jul 22, 2008·Diabetes & Metabolism·R Lupi, S Del Prato
Apr 15, 2008·Neurobiology of Aging·Saravanan S KaruppagounderGary E Gibson
Aug 16, 2012·The EMBO Journal·Estela Area-GomezEric A Schon
Jan 7, 2015·Biochimica Et Biophysica Acta·Sven W SauerStefan Kölker
May 29, 2016·Current Opinion in Genetics & Development·Estela Area-Gomez, Eric A Schon
Oct 4, 2008·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Flávio KapczinskiRobert M Post
Mar 2, 2018·Cell Death & Disease·Estela Area-GomezEric A Schon
Jun 6, 2007·Journal of Neuropathology and Experimental Neurology·Paula I MoreiraGeorge Perry
Jun 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Richard L JayarajFakhreya Yousuf Jalal
Dec 16, 2020·Journal of Hazardous Materials·Daniel Sanchez CarreteroChin-Pao Huang
Nov 24, 2020·Frontiers in Endocrinology·Jorge Berlanga-AcostaPedro A Valdés-Sosa
Jan 8, 2021·Stem Cell Research & Therapy·Zhuangzhuang XiaoHongwu Du
Sep 1, 2020·Neurobiology of Disease·Rishi R AgrawalMarta Pera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.