Mitochondrial Epigenetics: Non-Coding RNAs as a Novel Layer of Complexity

International Journal of Molecular Sciences
Giovanna C CavalcanteAmanda F Vidal

Abstract

Mitochondria are organelles responsible for several functions involved in cellular balance, including energy generation and apoptosis. For decades now, it has been well-known that mitochondria have their own genetic material (mitochondrial DNA), which is different from nuclear DNA in many ways. More recently, studies indicated that, much like nuclear DNA, mitochondrial DNA is regulated by epigenetic factors, particularly DNA methylation and non-coding RNAs (ncRNAs). This field is now called mitoepigenetics. Additionally, it has also been established that nucleus and mitochondria are constantly communicating to each other to regulate different cellular pathways. However, little is known about the mechanisms underlying mitoepigenetics and nuclei-mitochondria communication, and also about the involvement of the ncRNAs in mitochondrial functions and related diseases. In this context, this review presents the state-of-the-art knowledge, focusing on ncRNAs as new players in mitoepigenetic regulation and discussing future perspectives of these fields.

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Citations

Jan 15, 2021·Antioxidants·Rosanna Chianese, Riccardo Pierantoni
Apr 4, 2021·International Journal of Molecular Sciences·Luca X ZampieriPierre Sonveaux
Apr 9, 2021·Frontiers in Cell and Developmental Biology·Kai-Lieh LinTsu-Kung Lin
May 1, 2021·International Journal of Molecular Sciences·Andrea Stoccoro, Fabio Coppedè
Jun 3, 2021·International Journal of Molecular Sciences·Madiha RasheedZixuan Chen
Jun 11, 2021·RNA Biology·Huixin LiangQiyi Zhao
Apr 24, 2021·Genome Biology and Evolution·Sophie BretonLiliana Milani

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Methods Mentioned

BETA
environmental stress
acetylation
ubiquitination
xenograft

Software Mentioned

MOMP

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