Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration

FEBS Letters
R SchneiderH Weiss

Abstract

Genes that encode mitochondrial homologues to the bacterial enzymes of fatty acid synthesis were found in various eukaryotic species. Inactivation of these genes leads to a disturbed mitochondrial respiration and an increase in mitochondrial lysophospholipids. We postulate that there is a mitochondrial biosynthetic system providing fatty acids for phospholipid repair. The mitochondrial acyl carrier protein may also play another role, supporting the formation of the respiratory NADH:ubiquinone oxidoreductase.

References

Jan 26, 1990·European Journal of Biochemistry·S Mikolajczyk, S Brody
Sep 1, 1990·Microbiological Reviews·A Tzagoloff, C L Dieckmann
Jun 12, 1985·Biochimica Et Biophysica Acta·G Daum
Feb 1, 1989·Journal of Bacteriology·L HsuC O Rock
Apr 1, 1989·European Journal of Biochemistry·G von HeijneR G Herrmann
Dec 1, 1988·Journal of Molecular Evolution·R CedergrenD Sankoff
Apr 15, 1988·European Journal of Biochemistry·S Brody, S Mikolajczyk
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D YangC R Woese
Dec 1, 1980·European Journal of Biochemistry·F Lynen
Sep 1, 1993·Microbiological Reviews·K MagnusonJ E Cronan
Jan 1, 1993·Annual Review of Microbiology·L Katz, S Donadio
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown

❮ Previous
Next ❯

Citations

Jul 14, 2006·Journal of Inherited Metabolic Disease·Rolf J R J JanssenJan A M Smeitink
Nov 1, 2001·Trends in Parasitology·K S PaulP T Englund
Sep 21, 2012·Acta Crystallographica. Section D, Biological Crystallography·Andrei S HalavatyWayne F Anderson
Sep 10, 2008·Molecular and Cellular Biology·Melissa S SchonauerCarol L Dieckmann
Jun 15, 2005·Annual Review of Biochemistry·Stephen W White Rock
Mar 20, 2012·Neurobiology of Disease·Rainer ProhaskaRuth H Walker
Jul 3, 2003·Biochimica Et Biophysica Acta·Judy HirstJohn E Walker
Jun 4, 2013·The Biochemical Journal·Miranda S C WilsonAdolfo Saiardi
Nov 21, 2007·Chemistry & Biology·Gabor BunkocziUdo Oppermann
Sep 15, 2007·Biochimica Et Biophysica Acta·Rutger O VogelLeo G J Nijtmans
Jun 14, 2012·FEMS Yeast Research·Patrícia de Sousa LimaCélia Maria de Almeida Soares
Feb 15, 2000·The Journal of Biological Chemistry·V GueguenJ Bourguignon
Aug 26, 1998·The Journal of Biological Chemistry·H P StuibleE Schweizer
Sep 2, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Ali J MasudJ Kalervo Hiltunen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.