PMID: 16534320Mar 15, 2006Paper

Mitochondrial function in cardiomyocytes: target for cardioprotection

Current Opinion in Anaesthesiology
Dipak K Das, Nilanjana Maulik

Abstract

Cardiac diseases including ischemic heart disease, cardiomyopathy, hypertension, atherosclerosis and congestive heart failure are associated with cardiac cell death as a result of both necrosis and apoptosis. Mitochondria play an essential role in deciding whether a cell lives or dies. This review summarizes current knowledge on the mechanisms by which mitochondria exert such decision-making power. A wide variety of factors, either directly or indirectly, function in a synchronized manner to regulate the death versus survival signals. Mitochondrial bioenergetics and permeability transition pore plays a crucial role in this process, although several redox-sensitive genes, proteins and transcription factors, such as Bcl-2, Bax, nuclear factor kappa B, regulate the decision-making power of mitochondria, which have the final authority to decide whether a cell lives or dies. Mitochondrially generated reactive oxygen species are critically involved in the decision-making process, by functioning both as executioner by damaging the biomolecules, or as savior by virtue of their ability to perform redox signaling. It appears that mitochondria regulate the life and death of cardiac cells by manipulating several factors, including bioenerg...Continue Reading

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Citations

Nov 6, 2012·Journal of Molecular and Cellular Cardiology·Man LiuSamuel C Dudley
Jan 17, 2008·BioFactors·Leonardo Borges MuradLucia Marques Vianna
Nov 26, 2009·The American Journal of Chinese Medicine·Xing-Tai LiHui-Ying Chen
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Mark A Sussman
Jul 12, 2011·Physiological Reviews·Mark A SussmanMichael McGregor
Nov 21, 2007·Molecular and Cellular Biochemistry·Maria A S FernandesJosé B A Custódio

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