Mitochondrial function in development and disease.

Disease Models & Mechanisms
Marlies P RossmannLeonard I Zon

Abstract

Mitochondria are organelles with vital functions in almost all eukaryotic cells. Often described as the cellular 'powerhouses' due to their essential role in aerobic oxidative phosphorylation, mitochondria perform many other essential functions beyond energy production. As signaling organelles, mitochondria communicate with the nucleus and other organelles to help maintain cellular homeostasis, allow cellular adaptation to diverse stresses, and help steer cell fate decisions during development. Mitochondria have taken center stage in the research of normal and pathological processes, including normal tissue homeostasis and metabolism, neurodegeneration, immunity and infectious diseases. The central role that mitochondria assume within cells is evidenced by the broad impact of mitochondrial diseases, caused by defects in either mitochondrial or nuclear genes encoding for mitochondrial proteins, on different organ systems. In this Review, we will provide the reader with a foundation of the mitochondrial 'hardware', the mitochondrion itself, with its specific dynamics, quality control mechanisms and cross-organelle communication, including its roles as a driver of an innate immune response, all with a focus on development, disease...Continue Reading

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Citations

Sep 18, 2021·Cancer Science·Hiroki NagaseJason Lin
Oct 22, 2021·Biochemical Pharmacology·Walter H MoosKonstantina Sampani
Nov 2, 2021·Frontiers in Cell and Developmental Biology·Sepideh MostafaviLaurence A Bindoff

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POLRMT
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