PMID: 9545545Apr 18, 1998Paper

Mitochondrial gene expression and respiratory enzyme activities in cardiac diseases

Biochimica Et Biophysica Acta
B BornsteinJ Arenas

Abstract

Respiratory enzyme activities and steady-state level of two mitochondrial-encoded transcripts were quantified in heart muscle biopsies from patients suffering various types of cardiomyopathies unrelated to mitochondrial primary disorders. We have found that although the mitochondrial DNA copy number and the concentration of COI and ND4 transcripts remain fairly constant, there is an important increase (up to 6-fold) in respiratory enzyme activities affecting to several oxidative phosphorylation complexes. Idiopathic dilated cardiomyopathy shows the greatest increase, followed by ischemic heart and ventricular hypertrophy due to aortic stenosis. The results suggest an energetic compensatory mechanism in the heart muscle, in the absence of mitochondrial proliferation or activation of mitochondrial gene expression.

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Citations

Apr 9, 2009·Journal of Bioenergetics and Biomembranes·H Lemieux, C L Hoppel
Mar 21, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·J Marin-GarciaA Perez-Atayde
Aug 30, 2011·The International Journal of Biochemistry & Cell Biology·Hélène LemieuxErich Gnaiger
Jul 14, 2016·American Journal of Physiology. Endocrinology and Metabolism·Freya L Sheeran, Salvatore Pepe
Jun 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Mark A PeterzanOliver J Rider
May 8, 2000·Journal of Applied Physiology·D O Wilson, P Johnson

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