Mitochondrial gene sequences show fungal homology for Pneumocystis carinii

Molecular Microbiology
F J PixleyJ M Hopkin

Abstract

A 6.8 kilobase fragment of mitochondrial DNA from Pneumocystis carinii encodes for apocytochrome b, NADH dehydrogenase subunits 1, 2, 3, and 6, cytochrome oxidase subunit II, and the small subunit of ribosomal RNA. Comparative sequence analysis with a series of organisms representative of the fungal and protozoan groups shows that P. carinii has, consistently, an average similarity of 60% with the fungi but only 20% with the protozoa. The data indicate homology with the fungi for this opportunistic pathogen.

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Related Concepts

Cytochrome C Oxidase
Cytochrome c Oxidase Subunit VIa
RNA Conformation
Pathogenic Organism
DNA, Mitochondrial
Filamentous fungus
Pneumocystis Infections
Ribosomal RNA
UNKNOWN
Cytochrome b Group

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